Senior Researcher – Pharmacokinetics Expert

4 weeks ago

Vancouver, British Columbia, Canada AbCellera Full time

At AbCellera, we are breaking the barriers of conventional drug development to propel antibody-based medicines from target to clinic. Our team of scientists, engineers, and creatives believe that advancing science enhances lives. We have developed technologies to unlock high-value drug targets, including antibody-drug conjugates and T-cell engagers for cancer, and complex transmembrane proteins for indications such as metabolic and endocrine conditions, pain, and autoimmunity.

We are seeking an experienced and exceptional individual for the role of Senior Scientist – Pharmacokinetics, someone who has a passion for understanding how models can predict therapeutic responses to human disease. You will have the opportunity to help build out our pharm-tox capabilities so we can move programs faster and with less risk to the clinic, and you will work with protein science and protein engineering colleagues to help identify the best antibodies for the job. You will be responsible for constructing fit-for-purpose bioanalytical methods and running pharmacokinetic studies in close collaboration with our partners and external vendors.

Key Responsibilities:

  • Predicting and verifying appropriate dosing regimens to demonstrate antibody PK/PD relationships across a range of drug targets and disease areas
  • Developing bioanalytical strategies and establishing bioanalytical methods for protein therapeutics that are stage-appropriate (early research, GLP, etc)
  • Running pharmacokinetics studies to support antibody design and assessment
  • Designing and executing in vivo PK data packages tailored for individual programs
  • Collaborating with teams across the company to generate data and interpret them
  • Training and mentoring more junior scientists
  • Evaluating new technology and testing new models to better predict human illness
  • Reporting findings to our teams and partners to support data-driven decision making

Requirements:

  • You have a proven track record of building and interpreting bioanalytical datasets for antibodies
  • You are an expert in designing PK studies and conducting PK/PD data analysis, using WinNonlin or other similar software
  • You have a PhD in Biology, Pharmacology, or related discipline with 5-8 years of experience in an industry setting; if you have a MSc and 8-10 years of relevant experience in an industry setting, you will also be considered
  • You enjoy the teamwork that comes with working on complicated biological questions and building data sets that help to predict the success of therapies
  • You are good at communicating scientific and/or technical concepts with an emphasis on application
  • You are genuinely curious, with an interest in discussing innovative ideas in a highly collaborative and fast-paced environment
  • You have excellent documentation and organizational skills, as well as strong verbal and written communication skills
  • You have experience authoring sections of regulatory submissions and are well-versed in scientific and regulatory standards for bioassays of biologics (desirable)

What We Offer:

AbCellera's hiring range for this role is CAD $110,000 - $137,600 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution. You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you'll find we prioritize team building and connections across AbCellera.

About AbCellera:

AbCellera is a global company that discovers and develops antibody-based medicines that help people live longer, happier, and more productive lives. We are focused on bringing innovative medicines to patients, both by advancing our internal pipeline of programs and partnering with companies that have novel science or innovative technology.

We look for people with drive and energy. Idealists. People we love and people we trust. This may be unconventional, but it is the key to our success.

To Apply:

Please submit your application through our website and refer to Job ID 23212 in your cover letter. We apologize in advance, but we receive a large volume of applications and are only able to contact those who are selected for an interview.

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