Biotech Pharmacometrics Specialist

2 days ago


Vancouver, British Columbia, Canada AbCellera Full time

We are a global biotechnology company that discovers and develops antibody-based medicines to help people live longer, happier, and more productive lives. Our team consists of scientists, engineers, creatives, and business professionals who believe that advancing science enhances lives.

Our mission is to propel antibody-based medicines from target to clinic by breaking the barriers of conventional drug development. We have developed technologies to unlock high-value drug targets, including antibody-drug conjugates and T-cell engagers for cancer, and complex transmembrane proteins for indications such as metabolic and endocrine conditions, pain, and autoimmunity.

Salary: CAD $110,700 - $138,400 Annually

The successful candidate will be a Senior Research Scientist with expertise in Modeling and Simulations who can design, develop, and leverage Systems Pharmacology and Pharmacometric approaches to accelerate drug development of antibody therapeutics across various therapeutic areas and modalities.

This role involves collaborating with a team of modelers and bioinformaticians, and working with diverse project teams consisting of biologists, protein engineers, pharmacologists, clinicians, and others to guide program development. Your modeling and simulation approaches will integrate data from internal studies and external literature, supporting the design and interpretation of in vivo pharmacology studies as well as clinical trials.

Key Responsibilities:
  • Collaborating with scientists across Discovery and Development to develop and execute modeling strategies that contribute to project team discussions and guide therapeutic and dose selection decisions
  • Developing and implementing Quantitative Systems Pharmacology (QSP) and PK/PD modeling strategies to predict the behavior of therapeutics in disease-relevant systems and provide mechanistic understanding of the PK and PD profile
  • Partnering with the Pharmacology and Pharmacokinetics teams to support study design and analysis of data from in vivo studies
  • Collaborating with Clinical Pharmacology and Biostatistics experts to integrate modeling and simulation strategies to answer questions around clinical trial design and dose selection
  • Performing sensitivity analysis and hypothesis testing in order to identify key design parameters of interest for antibody molecules
  • Presenting findings and results in a concise manner to a diverse audience
Requirements:
  • A PhD in Mathematics, Pharmaceutical Sciences, Computational Biology, or a related field, and a minimum of 5-8 years of relevant experience, including experience in an industry environment
  • Hands-on experience in Quantitative Pharmacology and/or Pharmacometric approaches with a focus on QSP and PK/PD modeling in pre-clinical or early clinical development
  • Excellent understanding of theory, principles, and statistical aspects of mathematical modeling and simulation, including using numerical methods and parameter estimation/optimization
  • Hands-on experience using mathematical modeling software (e.g., Matlab, Simbiology, NONMEM, Julia, Monolix), as well as data analysis and visualization software (e.g., R, Python)
  • Good understanding of pharmacokinetic and pharmacodynamic principles for antibody and small molecule therapeutics
  • Ability to learn new areas of biological sciences and integrate knowledge and data to develop QSP models
  • Experience supporting and working with cross-functional teams in a dynamic environment
  • Demonstrated ability to find creative and functional solutions to complicated problems
  • Ability to express complex ideas in understandable ways, and to communicate effectively with people from different fields
About AbCellera:

We offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution. You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you'll find we prioritize teams and social groups to build community and connections across AbCellera.

Please refer to Job ID 23268 in your application through our website.



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