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Scientist III, Biology

3 months ago

Hamilton Ontario EH, Ontario, Canada Fusion Pharmaceuticals Full time

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; FPI-2059, a small molecule targeting neurotensin receptor 1 (NTSR1), currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. In addition, Fusion is pursuing combination programs between RCs and DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radiopharmaceutical manufacturing facility to meet supply demand for Fusion's growing pipeline of RCs.


The Scientist III, Biology role is based in Hamilton, Ontario.


Responsibilities
  1. The Scientist III, Biology will be expected to spend time in the lab to execute experiments as needed.
  2. Lead the scientific execution of drug discovery projects in alignment with departmental goals and timelines by designing and conducting experiments, setting objectives, delivering on project milestones, along with analyzing, interpreting and communicating results according to timelines.
  3. Identify and develop new techniques and assays to expand or enhance existing programs.
  4. Mentor junior scientists assigned to their projects/programs and supervise their work.
  5. Design and conduct biologic screening assays, mechanisms of action studies, therapeutic efficacy and biodistribution studies on radiopharmaceuticals in rodent models of cancer (or other disease indications of interest).
  6. Produce high quality and well documented data with strong attention to detail.
  7. Fostering scientific excellence, open scientific exchange, and deep scientific rigor.
  8. Present experimental results at both internal and external meetings.
Qualifications
  1. Ph.D. in Molecular/Cell Biology, Biology, Biochemistry or related field with 5+ years of industry experience.
  2. Experience in cancer Biology and preclinical drug development.
  3. Experience in drug screening and candidate drug selection is an asset.
  4. Previous experience in mentoring junior scientists is preferred.
  5. Experience with development and technical validation of in vitro bioassays and biologic screening assays.
  6. Experience with development and validation of in vivo cancer models in small rodents.
  7. Demonstrated ability to adapt to, perform, and develop unfamiliar methods in a rapidly evolving research environment.
  8. Demonstrated success in generation of actionable data to inform a go/no-decision point within a project/program.
  9. Experience with the safe handling of radioactive and biohazardous materials.
  10. Ability to work effectively in a multi-disciplinary team and communicate with colleagues at all levels.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

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