Scientist
3 weeks ago
12 MONTH CONTRACT + EXTENSIONS
5 DAYS A WEEK ON SITE IN NORTH YORK
SALARY: 45-55/HR
Main responsibilities:
The goal of this position is to contribute to generation of pre-master constructs and development of scalable GMP-compliant upstream processes. The candidate will have the opportunity to gain experience with sophisticated laboratory instruments and analytical methods.
The main responsibilities include:
• Interphase with Global Antigen Design team to screen new vaccine candidate, design and improve various constructs through molecular engineering techniques and perform genetic stability testing
• Collaborate with Upstream Scientists and lead a team of Technologists to plan and execute upstream process optimization and scale-up studies using technologies such as AMBR high-throughput bioreactor system, small and pilot scale bioreactors
• Perform in-house or coordinate supportive analytical testing including viral titration assays, FACS, SDS-PAGE, Western blot, HPLC, protein assays, and others
• Perform statistical data analysis, prepare technical reports and stakeholder presentations
• Lead and/or contribute to characterization studies using Design of Experiments methodology
• Contribute to tech transfer of processes to Global Clinical manufacturing or Manufacturing Sciences and Technology
• Contribute to Sanofi’s digital initiatives (eg. AI)
• Ensure compliance with Sanofi’s GxP quality, documentation requirements and HSE policies
Experience / Technical skills:
• Hands-on experience in molecular engineering tools (molecular cloning, nucleic acid analysis, and protein expression)
• Demonstrated experience with mammalian cell culture (eg. SF9, CHO, Vero)
• Experience in analytical techniques such as virus titration assays, FACS, protein assays, SDS-PAGE, Western blot, HPLC, and others
• Knowledge and experience with bioprocessing methods and process scale-up
• Mandatory Computer skills: Word, Excel, Powerpoint
• Expertise in Statistical analysis and software (JMP, GraphPad Prism etc) would be an asset
Education:
• Recommended PhD with 1+ years’ experience or MSc with 3+ years’ experience in a Biochemical Engineering / Life Sciences / Biology / Immunology / Biochemistry disciplines
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