Scientist

3 weeks ago


Toronto Ontario, Ontario, Canada Insight Global Full time

12 MONTH CONTRACT + EXTENSIONS

5 DAYS A WEEK ON SITE IN NORTH YORK

SALARY: 45-55/HR


Main responsibilities:


The goal of this position is to contribute to generation of pre-master constructs and development of scalable GMP-compliant upstream processes. The candidate will have the opportunity to gain experience with sophisticated laboratory instruments and analytical methods.


The main responsibilities include:


• Interphase with Global Antigen Design team to screen new vaccine candidate, design and improve various constructs through molecular engineering techniques and perform genetic stability testing

• Collaborate with Upstream Scientists and lead a team of Technologists to plan and execute upstream process optimization and scale-up studies using technologies such as AMBR high-throughput bioreactor system, small and pilot scale bioreactors

• Perform in-house or coordinate supportive analytical testing including viral titration assays, FACS, SDS-PAGE, Western blot, HPLC, protein assays, and others

• Perform statistical data analysis, prepare technical reports and stakeholder presentations

• Lead and/or contribute to characterization studies using Design of Experiments methodology

• Contribute to tech transfer of processes to Global Clinical manufacturing or Manufacturing Sciences and Technology

• Contribute to Sanofi’s digital initiatives (eg. AI)

• Ensure compliance with Sanofi’s GxP quality, documentation requirements and HSE policies


Experience / Technical skills:


• Hands-on experience in molecular engineering tools (molecular cloning, nucleic acid analysis, and protein expression)

• Demonstrated experience with mammalian cell culture (eg. SF9, CHO, Vero)

• Experience in analytical techniques such as virus titration assays, FACS, protein assays, SDS-PAGE, Western blot, HPLC, and others

• Knowledge and experience with bioprocessing methods and process scale-up

• Mandatory Computer skills: Word, Excel, Powerpoint

• Expertise in Statistical analysis and software (JMP, GraphPad Prism etc) would be an asset


Education:

• Recommended PhD with 1+ years’ experience or MSc with 3+ years’ experience in a Biochemical Engineering / Life Sciences / Biology / Immunology / Biochemistry disciplines


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