Genomic Bioinformatician

Hamilton Health Sciences is seeking a highly skilled Genomic Bioinformatician to join our team. As a key member of our laboratory, you will be responsible for managing, analyzing, and integrating large-scale gene sequence data.

• Develop and implement pipelines for processing next-generation sequencing data, from raw data to variant annotation and classification.
• Conduct bioinformatics analyses, troubleshoot pipeline issues, and assess the disease-causing potential of variants.
• Establish and maintain a secure and effective server system setup that ensures effective utilization of established bioinformatics pipelines.
• Liaise with laboratory scientists to submit variant classification data to appropriate databases.
• Troubleshoot and resolve issues related to software used to detect and interpret the clinical significance of sequence and copy number variants.
• Aid the disciplines quality management program and strive for operational excellence.
• Conduct horizon scanning to determine future needs of the HRLMP with respect to software applications, hardware needs, and data storage needs.
• Aid in the implementation and maintenance of existing and future computer systems in the laboratory.

• Master's Degree or Ph.D. in bioinformatics or computer science; or molecular biology and genetics and relevant experience in the field.
• Experience with programming languages such as Python, R, C++, MySQL, UNIX shell, and Java, and familiarity with using such languages in relation to an API.
• Experience working with next-generation sequencing data and developing NGS bioinformatics pipelines.
• Experience with full-stack development, databases, frameworks, and APIs.
• Experience with relevant public databases, such as Variant databases (gnomAD, ClinVar, COSMIC, OncoKB, etc.), Gene Ontology, UCSC Genome Browser.
• Demonstrated experience contributing to scientific research endeavors and the preparation of presentations, publications, SOPs, and resources for improved learning.

• Experience working with SNP-microarray analysis.
• Experience with epigenomic data analysis.
• Familiarity with statistical genomics.
• Familiarity with the ACMG/AMP/ASCO/CAP guidelines for variant annotation and classification.

Hamilton Health Sciences fosters a culture of patient and staff safety, whereby all employees are guided by our Mission, Vision, Values, and Values-Based Code of Conduct. We are an equal opportunity employer and will accommodate any needs under the Canadian Charter of Rights and Freedom, Accessibility for Ontarians with Disabilities Act, and the Ontario Human Rights Code.