Post Doctorate Fellow, Biointerfaces Institute

3 weeks ago

Hamilton, Canada McMaster University Full time

**Regular/Temporary**
- Temporary

**Job Title**
- POST DOCTORATE FELLOW, Biointerfaces Institute (ENG)**Job ID**
- 66006

**Location**
- Central Campus**Open Date**
- 11/04/2024

**Job Type**
- Limited Term (>12 months)

**Close Date**
- 11/18/2024

**Employee Group**
- Pos Doc (Union&NonUnion)

**Favorite Job**

**Department**
- ENG Biointerfaces Institute

**Contract Duration**
- 24.4 Months

**Hours per Week**
- 35

**Posting Details**

**Schedule**

Monday - Friday 8:30am - 4:30 pm
35 hours per week
Fully On-Site

**Education Level**
- Completed Ph.D. in Chemistry, Chemical Biology, Biochemistry or a similar discipline
- **Career Level**
- Prior experience working with functional nucleic acids or point of care diagnostics
- **Post Doctoral Fellowship**
**McMaster University, Faculty of Engineering, Biointerfaces Institute**

**Engineering a Brighter Future**

Applications are invited for a total of **two (2) Postdoctoral Fellowships** within the **Biointerfaces Institute** at McMaster University. Working closely with our partners at Methapharm Specialty Pharmaceuticals and St. Joseph’s Hospital, Hamilton, these positions will offer a unique opportunity to work with an interdisciplinary team of scientists and clinicians the interface of functional nucleic acids or point of care diagnostics.

We are currently developing lateral flow devices (LFDs) and fluorescence assays utilizing RNA-cleaving DNAzymes (RCD) for the simple and rapid detection of clinically relevant biomarkers. The project will involve: the optimization of methods used for the selection of protein-specific RCDs; the generation of RCDs for a range of key protein and polysaccharide biomarkers (mainly related to respiratory disease); the development of more advanced lateral flow and fluorescence assays that incorporate room temperature amplification and simple methods to quantify the outputs to allow detection and quantification of low abundance markers; the development of scalable methods for production of lateral flow devices and fluorescence assay kits; and the undertaking of initial clinical validation of any new tests using appropriate patient samples.

The lab is seeking a highly qualified individual to join our team to play a pivotal role in advancing our innovative point-of-care diagnostics.

**Duration and Funding**

The anticipated start date is as soon as possible. For applicants completing a PhD, documentation will be required to confirm that the Clearance to Graduate Letter with a PhD will be issued _prior_ _to _the fellowship start date. This fellowship will be funded as part of a NSERC Alliance grant. The target salary is $60,000.00 CAD/year plus benefits. This will be a 2-year term, with the possibility of an extension.

**Key Responsibilities**

**RCD Selection**: Develop automated methods for rapid selection of new RCDs, optimize selection protocols and new algorithms for identifying potential RCDs though next generation sequencing. Background in bioanalytical chemistry and molecular biology techniques (PCR, gel electrophoresis, DNA ligation, magnetic separation and/or sequence analysis) is required.

**Assay Development and Optimization**:Develop rapid fluorescence and lateral flow assays; integrate amplification methods into LFDs, generate multiplexed LFD assays. Background in biosensors would be an asset.

**LFD Production and Optimize Kit Performance**:Key goals will be to scale up production of LFDs and fluorescence assays kits, to work with external manufacturing partners to transfer protocols and design files, and to validate assay performance.

**Preliminary Validation on Clinical Samples**:In partnership with our collaborators at St. Joseph’s Hospital, evaluate the performance of optimized assay kits using a variety of respiratory samples from patients. Aid in the design of clinical trials for regulatory approval of new tests.
- Support the maintenance and organization of the laboratory
- Collaborate with the team on grant writing or preparing scientific articles when required

**Qualifications**
- Completed their Ph.D. in Chemistry, Chemical Biology, Biochemistry, or similar discipline
- Prior experience in solution
- and solid-phase assay development involving RCDs or DNA aptamers; a strong understanding of surface derivatization and printing; as well as prototyping and device development as well as developing protocols for targeted functional nucleic acids or lateral flow devices.
- Familiarity with different types of selection protocols such as SELEX, etc.
- Standard laboratory skills for nucleic acids research including pipetting, running PAGE gels, etc.
- Experience and expertise in printing biologicals using printers (such as BioDot, Sciex, etc.)
- Experience with analytical methods development and validation.
- Independent and proactive work ethic with the ability to thrive in a collaborative team environment.
- Excellent problem-solving skills and adaptability to evolving project needs.
- Effective com

  • Post Doctorate Fellow

    6 days ago

    Hamilton, Canada McMaster University Full time

    **Regular/Temporary** - Temporary **Job Title** - POST DOCTORATE FELLOW **Job ID** - 66753 **Location** - HSC- Central Campus **Open Date** - 12/17/2024 **Job Type** - Limited Term (

  • Post Doctorate Fellow

    4 weeks ago

    Hamilton, Canada McMaster University Full time

    **Schedule** Monday-Friday, 35 hours per week **Education Level** PhD degree **Career Level** Post-Doctoral Fellowship **POST-DOCTORAL FELLOWSHIP** The PDF will oversee the creation of a lay-accessible summary of archival materials local to Hamilton (for e.g., at Hamilton Health Sciences and Hamilton Public Library Local History and Archives) related to...

  • POST DOCTORATE FELLOW

    7 days ago

    Hamilton, Canada McMaster University Full time

    Job Description Post-doctoral position in physical function and aging (Canada) Division/Department: School of Rehabilitation Sciences, McMaster University Supervisor: Ayse Kuspinar, PT, PhD An enthusiastic and self-motivated post-doctoral fellow is sought to study physical function and mobility in older Canadians. The successful candidate...

  • Post Doctorate Fellow

    3 weeks ago

    Hamilton, Canada McMaster University Full time

    **Schedule** Monday to Friday, 35 hours per week, flexible schedule **Education Level** PhD in Cell Biology or Metabolism **Career Level** Post Doctorate Fellow Immuno-Metabolism **Overview Postdoctoral Fellow - Immuno-Metabolism** The David Braley Research Institute (affiliated with McMaster University) has an immediate opening for a full-time,...

  • Post Doctorate Fellow

    4 days ago

    Hamilton, Canada McMaster University Full time

    Posting Details Schedule Monday to Friday 35 hours per week Education Level PhD degree in a health or health-related field Career Level Experienced Compensation $50,000 per year, plus benefits Job Description AVOIDING DIABETES AFTER PREGNANCY TOGETHER WITH MOMS (ADAPT-M): BRIDGING CARE FROM THE THIRD TO THE FOURTH TRIMESTER ...

  • Post Doctorate Fellow

    6 days ago

    Hamilton, Canada McMaster University Full time

    Pathology and Molecular Medicine Analytical chemistry post-doctoral student research position **Development of clinical chemistry LC-MS-MS assays** Applications are invited for a 1-year post-doctoral fellowship position to develop clinical LC-MS-MS assays with the Hamilton Regional Laboratory Medicine Program (HRLMP) HRLMP clinical mass spectrometry...

  • Post Doctorate Fellow: Generative Artificial

    4 weeks ago

    Hamilton, Canada McMaster University Full time

    **Schedule** Monday-Friday, 35 hours per week **Education Level** PhD Degree **Career Level** Experienced **Postdoctoral Fellowship: Generative Artificial Intelligence and Post-secondary Teaching and Learning** The Paul R. MacPherson Institute for Leadership, Innovation and Excellence in Teaching plays a significant role in supporting the McMaster...

  • Post Doctorate Fellow

    4 weeks ago

    Hamilton, Canada McMaster University Full time

    **Regular/Temporary** - Regular **Job Title** - POST DOCTORATE FELLOW - Photonic Integrated Circuits**Job ID** - 65897 **Location** - Central Campus**Open Date** - 10/24/2024 **Job Type** - Contractually Limited

  • Post-doctoral Fellow

    4 weeks ago

    Hamilton, Canada McMaster University Full time

    **Regular/Temporary** - Temporary **Job Title** - Post-Doctoral Fellow - Numerical modelling and constitutive model development of frozen soil**Job ID** - 65651 **Location** - Central Campus**Open Date** - 10/07/2024 **Job Type** - Limited Term (>12 months) **Close Date** - 01/03/2025 **Employee Group** - Pos Doc (Union&NonUnion) **Favorite...

  • Post Doctorate Fellow

    4 weeks ago

    Hamilton, Canada McMaster University Full time

    **Regular/Temporary** - Temporary **Job Title** - Post Doctorate Fellow - Community-based Diabetes Research**Job ID** - 65096 **Location** - HSC- Central Campus**Open Date** - 10/25/2024 **Job Type** - Limited Term (=12 month) **Close Date** - 11/10/2024 **Employee Group** - Pos Doc (Union&NonUnion) **Favorite Job** **Department** -...

  • Post Doctorate Fellow in Health Studies

    4 weeks ago

    Hamilton, Canada McMaster University Full time

    **Schedule** Monday-Friday, 35 hours per week **Education Level** PhD in a Health or Health-related Field **Career Level** Experienced **Compensation** $55,000 per year + benefits **Post Doctorate Fellow in Health Studies** **Overview** We are seeking a highly qualified individual to join our team to engage in developing an exciting, new...

  • Post Doctoral Fellow

    3 days ago

    Hamilton, Canada McMaster University Full time

    **Regular/Temporary** - Temporary **Job Title** - Post Doctoral Fellow - Nuclear Operation and Facilities / Physics and Astronomy**Job ID** - 66329 **Location** - Central Campus**Open Date** - 11/22/2024 **Job Type** - Limited Term (=12 month) **Close Date** - 12/12/2024 **Employee Group** - Pos Doc (Union&NonUnion) **Favorite Job** **Department** -...

  • Post Doctorate Fellow

    4 weeks ago

    Hamilton, Canada McMaster University Full time

    **Regular/Temporary** - Temporary **Job Title** - POST DOCTORATE FELLOW**Job ID** - 60222 **Location** - Central Campus**Open Date** - 02/02/2024 **Job Type** - Limited Term (>12 months) **Employee Group** - Pos Doc (Union&NonUnion) **Favorite Job** **Department** - Chemical Engineering **Contract Duration** - 12.2 Months **Hours per Week** -...

  • Post Doctorate Fellow

    3 weeks ago

    Hamilton, Canada McMaster University Full time

    The normal hours of work are 35 hours per week for a full-time Postdoctoral Fellow, recognizing that the needs of the employee’s research training and the needs of the supervisor’s research program may require flexibility in the performance of the employee’s duties and hours of work._ **_ Annual Salary_**_: $53,000 CAD per year + benefits. _ - This...

  • Post Doctorate Fellow

    6 days ago

    Hamilton, Canada McMaster University Full time

    The David Braley Research Institute (affiliated with McMaster University) has an immediate opening for a full-time, experienced **Postdoctoral Fellow in Immuno-Metabolism **in the laboratory of Dr. Marc Jeschke - Professor of Surgery, Vice President of Research at Hamilton Health Sciences. Our laboratory focuses on translational research to attenuate...

  • Francophone Post-doctoral Fellow

    2 weeks ago

    Hamilton, Canada McMaster University Full time

    **Job Title**: FRANCOPHONE POST-DOCTORAL FELLOW **Location**: HSC - Central Campus / Remote **Job Type**: Limited Term **Employee Group**: Post Doc (Union&NonUnion) **Department**: Digital Society Lab **Contract Duration**: 12 months, with an option to renew for an additional 12 months **Hours per Week**: 35 **Overview** Applications are invited for...

  • Post Doctorate Fellow

    4 weeks ago

    Hamilton, Canada McMaster University Full time

    **Schedule** Monday to Friday 35 hours per week **Education Level** PhD degree in a health or health-related field **Career Level** Experienced **Compensation** $50,000 per year, plus benefits **AVOIDING DIABETES AFTER PREGNANCY TOGETHER WITH MOMS (ADAPT-M): BRIDGING CARE FROM THE THIRD TO THE FOURTH TRIMESTER** Together with Women’s College...

  • Post Doctorate Fellow

    3 weeks ago

    Hamilton, Canada McMaster University Full time

    **Schedule** Monday-Friday, 35 hours per week **Education Level** PhD degree **Career Level** Experienced **Post-Doctoral Fellowship Opportunity** Applications are invited for a Postdoctoral Fellowship in the **Department of Health Research Methods, Evidence, and Impact at McMaster University (HEI)**. This fellowship is in collaboration with EBSCO...

  • Post Doctorate Fellow, Cas

    2 weeks ago

    Hamilton, Canada McMaster University Full time

    **Regular/Temporary** - Temporary **Job Title** - POST DOCTORATE FELLOW, CAS (ENG)**Job ID** - 66108 **Location** - Central Campus**Open Date** - 11/08/2024 **Job Type** - Limited Term (=12 month) **Close Date** - 12/07/2024 **Employee Group** - Pos Doc (Union&NonUnion) **Favorite Job** **Department** - Computing and Software **Contract Duration** -...

  • Post Doctorate Fellow

    4 weeks ago

    Hamilton, Canada McMaster University Full time

    **Schedule** Monday to Friday 35 hours per week **Education Level** PhD in Nursing, Gerontology, or related field **Career Level** Experienced **Compensation** $51,000 per year, plus benefits **Postdoctoral Fellowship in** **Healthcare Service Delivery** Applications are invited for a Postdoctoral Fellowship in the **School of Nursing** at McMaster...