Scientist, Proteomics Specialist

4 days ago

Mississauga, Ontario, Canada Dalriada Drug Discovery Full time
About Dalriada Drug Discovery Inc.

Dalriada is a leading Canadian biotechnology organization specializing in small molecule therapies. Founded in 2017, we are a purpose-built, agile, and integrated drug discovery partner, accelerating the discovery and development journey of high-value new small molecule therapeutics from concept to IND.

Our unique operational model offers the global biotechnology industry a full suite of drug discovery, preclinical development, intellectual property, and business expertise to manage and execute tailored R&D programs.

We have supported integrated programs of public and venture capital-backed biotech companies, including Antibe, Janpix, Canopy Growth, Oxford Cannabinoid Technologies, atai Life Sciences, and Dunad Therapeutics.

Why Work with Us?

Our team of passionate and skilled drug discovery scientists is a key factor in our rapid success. We prioritize creating an environment that promotes professional, scientific, and personal growth and fosters agile innovation through integrative and interdisciplinary learning across all key drug discovery disciplines.

We pride ourselves on providing individuals a unique opportunity in small molecule R&D in Ontario to:

  • Make a direct impact and contribute intellectually to the creation of better medicines.
  • Design and evaluate new drug molecules across multiple therapeutic areas and be named inventors or direct contributors on patents.
  • Interact with management teams of innovative clinical-stage pharmaceutical and VC-backed biotech companies from across Canada, US, and Europe.
  • Conduct and advance cutting-edge science in a state-of-the-art R&D facility.
  • Collaborate with our expert interdisciplinary drug discovery scientists in medicinal & computational chemistry, cell & molecular biology, biophysics & biochemistry, ADME, and proteomics.
  • Work closely with our senior leadership and executive team of expert drug discovery scientists, innovators, global pharmaceutical industry executives, and entrepreneurs.
Job Summary

We are seeking a skilled and experienced Scientist in Proteomics to join our dynamic research team. In this role, you will play a crucial part in designing, executing, and analyzing proteomics experiments, leveraging your expertise in advanced mass spectrometry techniques and data analysis.

Your contributions will enhance our understanding of complex biological systems and support the development of innovative therapeutic solutions. This position presents an exciting opportunity to apply cutting-edge proteomics technologies to accelerate drug discovery and development.

Key Responsibilities
  • Design and execute proteomic experiments to identify and validate drug targets, investigate target engagement, and assess drug response in cellular and animal models.
  • Utilize advanced mass spectrometry techniques, such as discovery and targeted proteomics, to profile protein expression, protein-drug interactions, and protein-protein interactions.
  • Develop and optimize sample preparation protocols to ensure compatibility with downstream proteomics analyses and maximize the coverage of the proteome.
  • Apply bioinformatics tools and statistical methods to analyze proteomic data and identify biomarkers, pathways, and networks relevant to drug discovery.
  • Provide scientific leadership and guidance to junior scientists and research associates involved in proteomics experiments, fostering a collaborative and innovative work environment.
  • Stay abreast of emerging technologies, methodologies, and trends in proteomics and drug discovery, and evaluate their potential application in our research projects.
Requirements

We are seeking a candidate with:

  • A PhD or MSc in Chemistry, Biochemistry, Chemical Biology, or a related discipline.
  • Knowledge and experience in discovery proteomics and/or targeted proteomics.
  • Knowledge of the application of proteomics in drug discovery, such as covalent programs and targeted protein degradation.
  • 2 years of experience in proteomics workflows, including chemoproteomics, affinity purification-mass spectrometry, and proximity labeling.
  • 2 years of expertise in operating orbitrap and/or TOF mass spectrometers.
  • Working knowledge of statistics and experience in a scripting language (e.g., R, Python).
  • Proficiency with open-source and vendor-specific proteomic software, such as Skyline, Proteome Discoverer, MS Fragger, etc.

We are looking for a candidate who is driven by scientific excellence and cost/process efficiency, able to analyze, interpret, and present scientific data, and propose next steps in experimental design and project strategy.

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