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Scientist, Proteomics Specialist
2 months ago
Dalriada Drug Discovery Inc. is a leading Canadian biotechnology organization specializing in small molecule therapies. Founded in 2017, the company has established itself as a unique and agile drug discovery partner, accelerating the discovery and development journey of high-value new small molecule therapeutics from concept to IND.
Our Turn-Key operational model offers the global biotechnology industry a comprehensive suite of drug discovery, preclinical development, intellectual property, and business expertise to manage and execute tailored R&D programs. To date, Dalriada has supported integrated programs of public and venture capital-backed biotech companies, including Antibe, Janpix, Canopy Growth, Oxford Cannabinoid Technologies, atai Life Sciences, and Dunad Therapeutics.
Why Work with Us?Our team of passionate and skilled drug discovery scientists is a key factor in Dalriada's rapid success. Since inception, the company has prioritized creating an environment that promotes professional, scientific, and personal growth and fosters agile innovation through integrative and interdisciplinary learning across all key drug discovery disciplines. We pride ourselves on providing individuals a unique opportunity in small molecule R&D in Ontario to:
- Make a direct impact and contribute intellectually to the creation of better medicines. Our scientists design and evaluate new drug molecules across multiple therapeutic areas and are named inventors or direct contributors on patents.
- Interact directly with management teams of innovative clinical-stage pharmaceutical and VC-backed biotech companies from across Canada, US, and Europe.
- Conduct and advance cutting-edge science in a state-of-the-art R&D facility.
- Collaborate with Dalriada's expert interdisciplinary drug discovery scientists in medicinal & computational chemistry, cell & molecular biology, biophysics & biochemistry, ADME, and proteomics (>70% PhD).
- Work closely with Dalriada senior leadership and executive team of expert drug discovery scientists, innovators, global pharmaceutical industry executives, and entrepreneurs, who collectively have > 145 patents, pharma transactions > $2B, 6 companies founded, >215 years of drug discovery experience, led > 100 drug discovery programs, and brought drugs to the clinic and market.
- Be at the forefront with Ontario's largest and one of Canada's fastest-growing drug discovery organizations.
- Learn new things every day in a fast-paced, stimulating, values-based company committed to driving growth, delivering solutions, being accountable, and creative.
We are seeking a skilled and experienced Scientist in Proteomics to join our dynamic research team. In this role, you will play a crucial part in designing, executing, and analyzing proteomics experiments, leveraging your expertise in advanced mass spectrometry techniques and data analysis. Your contributions will enhance our understanding of complex biological systems and support the development of innovative therapeutic solutions. This position presents an exciting opportunity to apply cutting-edge proteomics technologies to accelerate drug discovery and development.
Key ResponsibilitiesThe successful candidate will be responsible for:
- Designing and executing proteomic experiments to identify and validate drug targets, investigate target engagement, and assess drug response in cellular and animal models.
- Utilizing advanced mass spectrometry techniques, such as discovery and targeted proteomics, to profile protein expression, protein-drug interactions, and protein-protein interactions.
- Developing and optimizing sample preparation protocols to ensure compatibility with downstream proteomics analyses and maximize the coverage of the proteome.
- Applying bioinformatics tools and statistical methods to analyze proteomic data and identify biomarkers, pathways, and networks relevant to drug discovery.
- Providing scientific leadership and guidance to junior scientists and research associates involved in proteomics experiments, fostering a collaborative and innovative work environment.
- Staying abreast of emerging technologies, methodologies, and trends in proteomics and drug discovery, and evaluating their potential application in our research projects.
The ideal candidate will possess:
- A PhD or MSc in Chemistry, Biochemistry, Chemical Biology, or a related discipline.
- Knowledge and experience in discovery proteomics and/or targeted proteomics.
- Knowledge of the application of proteomics in drug discovery, such as covalent programs and targeted protein degradation.
- 2 years of experience in proteomics workflows, including chemoproteomics, affinity purification-mass spectrometry, and proximity labeling.
- 2 years of expertise in operating orbitrap and/or TOF mass spectrometers.
- Working knowledge of statistics and experience in a scripting language (e.g., R, Python).
- Proficiency with open-source and vendor-specific proteomic software, such as Skyline, Proteome Discoverer, MS Fragger, etc.
- Ability to analyze, interpret, and present scientific data, and propose next steps in experimental design and project strategy.
- Driven by scientific excellence and cost/process efficiency.
- Offers timely results through sound judgment and scientific knowledge.
- Thinks critically and generates creative solutions to challenging scientific questions.
- Approaches work with an entrepreneurial mindset, working independently and seeking professional input when necessary.
- Superior communication skills (written and verbal) and interpersonal skills.
- Fast learner, flexible, and innovative, able to work collaboratively within cross-functional teams.
- Able to manage multiple projects simultaneously and meet aggressive project timelines.
