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Phd Position: Dopaminergic Control of Brainstem

3 months ago

Sherbrooke, Canada Université de Sherbrooke Full time

**PhD position: Dopaminergic control of brainstem locomotor circuits**:

- Réf **ABG-119973**
- Sujet de Thèse- 05/02/2024- Financement public/privé- Université de Sherbrooke- Lieu de travail- Sherbrooke - Canada- Intitulé du sujet- PhD position: Dopaminergic control of brainstem locomotor circuits- Champs scientifiques- Psychologie, neurosciences
- Mots clés- Dopamine, neuroscience, locomotion**Description du sujet**:
The locomotor role of dopaminergic cells is classically attributed to their ascending projections to the basal ganglia that project to the Mesencephalic Locomotor Region (MLR), a brainstem region that controls locomotion. However, descending projections to the MLR were uncovered (Ryczko et al. PNAS 2013, PNAS 2016, J Neurosci 2017, J Neurosci 2020). In lamprey, this descending pathway increases locomotor activity. In mammals, the role of such innervation remains to be determined.
The student will address this issue using patch-clamp electrophysiology and optogenetics in brain slices, calcium imaging, viral tracing, in vivo optogenetics and movement analysis in mice. The new knowledge will provide a better understanding of the relation between dopaminergic and locomotor neurons and help identify new clinical strategies to improve locomotor function in Parkinson’s disease.

**Prise de fonction**:

- 02/09/2024**Nature du financement**:

- Financement public/privé**Précisions sur le financement**:

- Canadian Institute for Health Research**Présentation établissement et labo d'accueil**:

- Université de SherbrookeHOST LABORATORY: the lab of Pr. Ryczko has expertise in the neural control of locomotion and published articles in excellent journals (PNAS, Journal of Neuroscience, Trends in Neurosciences ). The lab receives grant support by the CIHR, NSERC, FRQS, CFI and ERC. We are equipped for optogenetics, viral injections, patch-clamp recordings, confocal and two photon calcium imaging, high-resolution movement analysis based on deep learning, and microscopy (confocal, light-sheet, two-photon, STED).

**Site web**:
**Intitulé du doctorat**:

- Doctorat en Physiologie**Pays d'obtention du doctorat**:

- Canada**Etablissement délivrant le doctorat**:

- Université de Sherbrooke-
- 15/03/2024