Senior Research Scientist, Biochemistry and Computational Structural Biology
6 days ago
We are seeking a highly motivated Research Scientist to join our team at AbCellera, a leading biotech company pioneering the discovery and development of antibody-based medicines. As a key member of our research team, you will play a critical role in implementing in-silico structural tools and processes in the areas of protein and antibody engineering.
Key Responsibilities- Design, implement, and evaluate in-silico protein engineering activities in support of our developing platform for antibody reformatting processes and optimization of therapeutic assets.
- Organize, support, and collaborate with other team members to meet project deliverables and timelines.
- Apply expertise in protein engineering to improve the speed and quality of protein biotherapeutics development.
- Work independently to identify project needs and develop solutions.
- PhD in Biochemistry, Biophysics, Structural Biology, Computational Biology, Computer Science, or a related field, or a MSc with 5+ years of related experience in a biological research setting.
- Excellent programming skills in Python, as well as a comprehensive understanding of techniques to perform in-silico protein structure design using tools such as Rosetta software suite.
- Working knowledge of antibody structure and function, and familiarity with techniques applicable to the molecular design, engineering, and experimental evaluation of antibody and/or antigen libraries for protein engineering purposes.
- Awareness of experimental analytic and biophysics techniques used for antibody characterization, e.g. size exclusion chromatography (SEC), hydrophobic interaction chromatography (HIC), capillary electrophoresis (CE), light scattering (DLS, MALS), differential scanning calorimetry (DSC), isoelectric focusing (IEF), surface plasmon resonance (SPR), etc.
- A competitive salary range of CAD $75,200 - $94,000 annually, commensurate with your education and job-related knowledge, skills, and experience.
- Equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution.
- A CAD $1,500 annual Active Lifestyle Allowance, annual vacation, opportunity for flexible work arrangements, professional development opportunities, and comprehensive health benefits.
- Scientific and technical mentorship is a priority, and we prioritize teams and social groups to build community and connections across AbCellera.
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