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Senior Research Scientist

2 months ago

Vancouver, British Columbia, Canada AbCellera Full time
About the Role

We are seeking an experienced and motivated Senior Research Scientist to join our team at AbCellera. As a key member of our research organization, you will play a critical role in advancing our understanding of biophysics and its application to antibody-based medicines.

Key Responsibilities
  • Provide leadership in the application of biophysical characterization methods to assess the binding interactions and developability of biotherapeutics
  • Establish strategy, develop workflows, and integrate new technologies to assess antibody binding properties, including kinetics, affinity, epitope, and mechanism of action
  • Design and execute detailed early formulation and stability studies to identify developable lead molecules
  • Analyze and interpret complex data sets, including analytical, biophysical, binding, and in silico assessments, to nominate lead candidate antibody molecules for clinical development
  • Provide protein science and biotherapeutic leadership within multidisciplinary drug discovery program teams
  • Mentor junior scientists within a rapidly growing and dynamic team
  • Collaborate with teammates to leverage automation, data science, bioinformatics, and machine learning to expand the throughput of antibody screening, including data curation, analysis, and interpretation of large data sets
  • Act as a subject matter expert for antibody developability and biophysical characterization
Requirements
  • PhD in Biophysics, Biochemistry, or Structural Biology, plus 5-8 years of experience in an industry setting; or MSc and 8-10 years of relevant experience in an industry setting
  • Demonstrated expertise in the evaluation of protein interactions and mechanism of action using SPR, BLI, ITC, ELISA, Kinexa, AUC, or related technologies
  • Experience applying analytical SEC, HIC, IEX, light scattering, CE-SDS, cIEF, DSF, DSC, mass spectrometry, or related techniques to assess sample quality and developability of biotherapeutics
  • In-depth understanding of antibody sequences and structure, as well as common modifications and physical and chemical stability risks
  • Experience managing and interacting with electronic lab notebook environments, and laboratory information and inventory management systems
  • Strong interpersonal skills with the ability to work collaboratively as a member of a cross-functional team
  • Excellent decision-making and troubleshooting skills, as well as effective documentation and organizational skills with a high attention to detail
  • Supporting preclinical development of biologics, particularly bi-/multispecific antibodies, and helping to generate data that supported their clinical development is not new to you
  • Comfortable writing formal reports with interpretations based on data generated in complex biological systems to build mechanistic confidence in a target
  • Self-motivated, with the initiative to meet project goals under tight timelines
About AbCellera

AbCellera is a global company that discovers and develops antibody-based medicines that help people live longer, happier, and more productive lives. We are focused on bringing innovative medicines to patients, both by advancing our internal pipeline of programs and partnering with companies that have novel science or innovative technology.

We look for people with drive and energy. Idealists. People we love and people we trust. This may be unconventional, but it is the key to our success.