In Vitro Biology Associate Scientist
4 weeks ago
Key Responsibilities
- Oversees the design, coordination, execution, and analysis of in vitro pharmacology experiments aimed at advancing innovative technologies for antibody-drug conjugates (ADCs).
- Functionally characterizes small molecules, antibodies, bioconjugates, or ADCs through various cell-based assays and techniques, including flow cytometry, high-throughput screening, live cell imaging, and 3D tissue culture, to support project advancement.
- Leads and implements novel assay development initiatives, designing and troubleshooting methods to profile the mechanisms of action of ADCs across diverse payload classes.
- Utilizes knowledge of cancer biology, medicinal chemistry, and other scientific methodologies to conduct advanced analyses and interpret data effectively.
- Collaborates effectively with team members and other departments to coordinate decision-making experiments for various projects, regularly sharing updates on progress.
- Prepares and presents data summaries for group meetings, outlining results and future steps, and acts as a representative in specific projects.
- Provides leadership, mentorship, and scientific guidance to junior staff members.
- Supports mammalian tissue culture activities, ensuring proper expansion, cryopreservation, and database updates of cell lines.
- May co-author or author scientific publications, conference presentations, patents, and regulatory documents.
- May represent Zymeworks at relevant scientific conferences.
- Adheres to standard procedures for data generation, documentation, and archiving, maintaining an accurate electronic laboratory notebook.
- Conducts all activities in compliance with scientific standards, safety regulations, and established company policies, contributing to a safe and efficient laboratory environment.
- Actively promotes an environment of effective collaboration among employees, management, and external partners.
Education and Experience
- Requires a PhD in Molecular Biology, Immunology, or Biochemistry, with a minimum of 1-2 years of relevant experience, or an equivalent combination of education and experience.
- Demonstrated experience in cell-based or biochemical assay development.
- Understanding of in vitro cancer models and therapeutic mechanisms of action is essential.
- Experience in the characterization and analysis of biotherapeutics, including small molecules, antibodies, and ADCs, is advantageous.
- Familiarity with high-throughput screening assays and workflows is beneficial.
Skills and Abilities
- Ability to manage multiple projects, prioritize tasks, allocate resources, and meet deadlines.
- Strong analytical and problem-solving skills.
- Commitment to the highest professional standards and confidentiality where required.
- Excellent organizational and time management skills, with the ability to thrive in a fast-paced environment.
- Strong interpersonal skills, capable of working collaboratively within a cross-functional team and maintaining effective working relationships.
- Exceptional communication skills, including scientific writing and oral presentation abilities.
- Demonstrated leadership and mentorship capabilities.
- Results-oriented mindset.
- In-depth knowledge of antibody or ADC structure/function.
- Familiarity with GraphPad and FlowJo software, or similar tools, is considered an asset.
- Advanced proficiency in techniques such as flow cytometry, high-content analysis, mammalian tissue culture, and immunological/co-culture assays is advantageous.
Total Rewards
We offer a comprehensive total rewards package, including competitive salaries, generous benefits, and excellent opportunities for professional growth. Our compensation is regularly benchmarked against leading biotechnology companies. The Canadian base salary range for this full-time position is competitive, with additional bonuses and equity options available.
Our team enjoys industry-leading vacation and paid time off, excellent health and wellness benefits, and various employee programs.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or disability.
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