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In Vitro Biology Associate Scientist
3 months ago
Key Responsibilities
- Manages the planning, coordination, execution, and evaluation of in vitro pharmacology studies aimed at advancing innovative technologies for antibody-drug conjugates (ADCs).
- Characterizes small molecules, antibodies, bioconjugates, or ADCs through various cellular assays and techniques, including flow cytometry, high-throughput screening, live cell imaging, and 3D tissue culture, to facilitate project progression.
- Drives and implements new assay development projects, designing and troubleshooting innovative methods to assess the mechanisms of action of ADCs across diverse payload classes.
- Utilizes expertise in cancer biology, medicinal chemistry, and other scientific approaches to conduct advanced analyses and interpret data effectively.
- Collaborates with cross-functional teams to coordinate the execution of critical experiments for various projects, providing regular updates on progress.
- Prepares and presents data summaries for team meetings, outlining results and future directions, and serves as a representative for specific projects.
- Offers leadership, mentorship, and scientific guidance to junior team members.
- Assists with mammalian tissue culture tasks, ensuring proper maintenance, cryopreservation, and database updates for cell lines.
- May contribute to scientific publications, conference presentations, patents, and regulatory documents.
- May represent Zymeworks at relevant scientific conferences.
- Follows Zymeworks' standard operating procedures for data generation, documentation, and archiving, maintaining an accurate electronic laboratory notebook.
- Conducts all work in compliance with scientific standards, occupational safety regulations, and established Zymeworks policies, contributing to a safe and efficient laboratory environment.
- Actively promotes a culture of effective collaboration among employees, management, and external partners.
Education and Experience
- Requires a PhD in Molecular Biology, Immunology, or Biochemistry, with a minimum of 1-2 years of relevant experience, or an equivalent combination of education and experience.
- Proven experience in developing cell-based or biochemical assays.
- Strong understanding of in vitro cancer models and therapeutic mechanisms of action.
- Experience in characterizing and analyzing biotherapeutics, including small molecules, antibodies, Fc-fusion proteins, and ADCs, is advantageous.
- Familiarity with high-throughput screening assays and workflows is a plus.
Skills and Abilities
- Ability to manage multiple projects, prioritize tasks, allocate resources, and meet deadlines.
- Exceptional analytical and problem-solving skills.
- Commitment to maintaining professional standards and confidentiality.
- Strong organizational and time management abilities, with a capacity to thrive in a fast-paced, dynamic environment.
- Excellent interpersonal skills, with the ability to work collaboratively within a cross-functional team and establish effective working relationships.
- Outstanding communication skills, including proficiency in scientific writing and oral presentations, with the ability to convey data effectively in large meetings.
- Demonstrated leadership and mentorship capabilities.
- Results-oriented mindset.
- In-depth knowledge of antibody or ADC structure/function.
- Familiarity with GraphPad and FlowJo software, or similar tools, is considered an asset.
- Advanced proficiency in techniques such as flow cytometry, high-content analysis, fluorescence imaging, and immunological/co-culture assays is advantageous.
Total Rewards
We provide a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. Our compensation is regularly benchmarked against leading biotechnology companies. The Canadian base salary range for this full-time position is competitive, with additional bonuses, equity, and benefits.
Our team enjoys:
- Industry-leading vacation and paid time off
- Excellent health and wellness benefits
- Paid time off for community volunteering
- Matching retirement savings program
- Employee Share Purchase Program
- Employee Equity Program
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or disability.
