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Postdoctoral Fellowship, Computational Biology
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Aberrant lipid metabolism is linked genetically to risk of Alzheimer’s Disease (AD), Parkinson’s Disease with Dementia (PDD), and Dementia with Lewy Bodies (DLB). It is not known how lipid metabolism mechanistically contributes to cognitive decline nor whether onset of dementia can be delayed by intervening in lipid metabolism. We hypothesize that specific disruptions in phospholipid and sphingolipid metabolic networks act synergistically with α-synuclein (α-syn) and amyloid-β (Aβ) to elicit cognitive decline. Machine learning models have been explored to determine diagnostic markers and therapy targets however they were not able to provide understanding of causal relationships with the lipidome. In this project we will be working on the development of mathematical methods for the determination of causal relationships between lipid molecules and disease development for assessment of early disease markers and targets for treatment before significant brain damage is incurred. Project is collaboration between NRC and University of Ottawa.
**Education**:
Ph.D. in applied mathematics, computer science, machine learning, bioinformatics, computational biology, theoretical physical chemistry or physics.
For information on certificates and diplomas issued abroad, please see Degree equivalency
**Experience**:
- Experience in programming with Python, Matlab or R.
- Experience in mathematical modeling, machine learning & inference and causality analysis.
- Experience in metabolomics and lipidomics analysis would be considered an asset.
**Language Requirements**:
English
Information on language requirements and self-assessment tests
**Condition of Employment**:
- Reliability Status
**Who is eligible?**:
- Fellowships will be for two years contingent on satisfactory progress achieved during the first year.
- Fellows will work in a lab under the direct supervision of an NRC researcher.
**Application Requirements**:
- Resume
- Statement of Interest in the project (maximum one page in length)
- PhD Transcript - an electronic copy is sufficient, it does not have to be an official version.
- List of Publications
In addition, applicants who best meet the requirements of the position will be asked to provide three letters of recommendation at a later stage of the competition process.
**Relocation**:
Relocation assistance will be determined in accordance with the NRC's directives.
**Compensation**:
The intent of this hiring action is to staff through the Postdoctoral Fellowships Program at the RCO-2/AsRO level, which is an early-career level position with a salary range of $74,230 to $103,093.
NRC employees enjoy a wide-range of competitive benefits including comprehensive health and dental plans, pension and insurance plans, vacation and other leave entitlements.
**Notes**:
- The incumbent must adhere to safe workplace practices at all times.
- We thank all those who apply, however only those selected for further consideration will be contacted.
Please direct your questions, with the requisition number (16599) to:
Telephone: 343-552-7798
**Closing Date**: 27 March 2023 - 23:59 Eastern Time
