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Postdoctoral Fellowship, Mrna-encoded Bispecific

1 month ago


Ottawa, Canada National Research Council Canada Full time

Bispecific antibody therapeutics have been hailed as a major breakthrough in cancer therapy and have increased survival rates for many forms of difficult-to-treat cancers. Nevertheless, the common challenges for all biologics are manufacturing, product stability and cost, limiting their use for all patients.
- and tri-specific immune cell engagers using an mRNA-lipid nanoparticle (LNP) delivery strategy. This project offers a unique opportunity to work with both NRC scientists and collaborate with clinicians at OICR and BC Cancer.

**Education**:
Ph.D in Molecular and Cellular Biology, Immunology, or related field‎.

For information on certificates and diplomas issued abroad, please see Degree equivalency

**Experience**:

- Significant knowledge in antibody engineering, phage display and protein expression and/or cancer immunology.
- Experience working with antibody libraries, antibody isolation, and antibody expression in both prokaryotic and eukaryotic systems.
- Experience working with immune cell lines and/or primary immune cell populations.
- Experience with flow cytometry and/or other cellular immune assays.

**Asset**:

- Experience working with mRNA production technologies and mRNA-LNP encapsulation.
- Experience working with syngeneic and/or xenograft murine cancer models.

**Language Requirements**:
English

Information on language requirements and self-assessment tests

**Condition of Employment**:
Reliability Status

**Who is eligible?**:

- Fellowships will be for two years contingent on satisfactory progress achieved during the first year.
- Fellows will work in a lab under the direct supervision of an NRC researcher.
- Exceptions may be considered to recognize personal or family related leave. Please connect with us using the contact information below to discuss in more detail.

**Application Requirements**:

- Resume
- Statement of Interest in the project (maximum one page in length)
- PhD Transcript - an electronic copy is sufficient, it does not have to be an official version.
- List of Publications

In addition, applicants who best meet the requirements of the position will be asked to provide three letters of recommendation at a later stage of the competition process.

**Compensation**:
The intent of this hiring action is to staff through the Postdoctoral Fellowships Program at the AsRO level, which is an early-career level position with a salary range of $74,230 to $103,093.

NRC employees enjoy a wide-range of competitive benefits including comprehensive health and dental plans, vacation, sick, and other leave entitlements, disability insurance and pension plans.

**The NRC Advantage**:
The National Research Council of Canada (NRC) is the Government of Canada's largest research organization supporting industrial innovation, the advancement of knowledge and technology development. We collaborate with over 70 colleges, universities and hospitals annually, work with 800 companies on their projects, and provide advice or funding to over 8000 Small and Medium-sized Enterprises (SMEs) each year.

We bring together the brightest minds to deliver tangible impacts on the lives of Canadians and people around the world. And now, we want to partner with you. Let your expertise and inspirations make an impact by joining the NRC.

Help us solve problems for Canada. Grow your career with us today

**Notes**:

- Relocation assistance will be determined in accordance with the NRC's directives.
- The incumbent must adhere to safe workplace practices at all times.
- We thank all those who apply, however only those selected for further consideration will be contacted.

Please direct your questions, with the requisition number (21311) to:
Telephone: 613-949-7685
**Closing Date**: 26 March 2024 - 11:59 Eastern Time


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