Senecence and Vascular Development

3 weeks ago

Montréal, Canada Université du Quebec à Montréal Full time

**Senecence and vascular development**:

- Réf
- **ABG-110056**
- Sujet de Thèse- 07/01/2023- Contrat doctoral- Université du Quebec à Montréal- Lieu de travail- Montréal - Canada- Intitulé du sujet- Senecence and vascular development- Champs scientifiques- Biologie
- Biochimie
- Biotechnologie
- Mots clés- Angiogenesis, premature aging, retinopathy, cell plasticity, vision, stemless**Description du sujet**:

- A functional vascular network is a prerequisite for normal embryonic development, tissue repair and engineering. Deciphering the cellular and molecular mechanisms that initiate and regulate blood vessel growth and regression in the retina in homeostatic conditions is key to understand vascular retinopathies. We use unbiased high-throughput screening methods of Single cell RNAseq, combined with microscopy imaging and biochemical analysis to identify angiocrine factors regulating different aspects of vessel remodeling in the eye. We found recently that cellular senescence can occur from the earliest stages of embryonic development and influence endothelial cell’s function. Understanding the cellular and molecular mechanisms of developmental senescence and the identification of new molecular signatures regulating endothelial cell plasticity and specification is of great interest in order to manipulate theses pathways to counteract retinopathy.A functional vascular network is a prerequisite for normal embryonic development, tissue repair and engineering. Deciphering the cellular and molecular mechanisms that initiate and regulate blood vessel growth and regression in the retina in homeostatic conditions is key to understand vascular retinopathies. We use unbiased high-throughput screening methods of Single cell RNAseq, combined with microscopy imaging and biochemical analysis to identify angiocrine factors regulating different aspects of vessel remodeling in the eye. We found recently that cellular senescence can occur from the earliest stages of embryonic development and influence endothelial cell’s function. Understanding the cellular and molecular mechanisms of developmental senescence and the identification of new molecular signatures regulating endothelial cell plasticity and specification is of great interest in order to manipulate theses pathways to counteract retinopathy.**Nature du financement**:

- Contrat doctoral**Précisions sur le financement**:

- bourse de doctorat (subventions de recherche)**Présentation établissement et labo d'accueil**:

- Université du Quebec à Montréal- Dr. Oubaha is a molecular and cellular biologist with specific training and expertise in vascular biology. Her work led to significant findings on the role of cellular senescence in vascular remodeling in retinopathies. Dr Oubaha is a professor at biological science department at Université du Québec à Montréal. She is a Canada Research chair in senescence and vascular development from the Canadian Institutes of Health research.- Dr Oubaha’s translational research program on Senescence and Vascular Development focuses on understanding endothelial cell function in retinopathies to find effective and streamlined therapeutic strategies not only for vascular eye diseases but also for other vascular-associated pathologies like atherosclerosis and cancer.She is member of the Center of Excellence in Research on Orphan Diseases - Fondation Courtois (CERMO-FC) founded at UQAM brings together more than 60 researchers across Quebec and internationally. The Center’s mission is to develop and deepen knowledge on orphan diseases through fundamental and applied research, and in doing so, to identify therapeutic targets to improve patient care and follow-up. and their quality of life. At the same time, CERMO-FC is preparing the next generation in this field through education and training.

She is Member also of the Vision Health Research Network which receives its core funding from the Quebec government via the Fonds de recherche du Québec-Santé (FRQS). The FRQS fostered the creation of research networks in the early 1990s to help mobilize and structure various research communities to enhance their productivity and competitiveness on the national and international stage, and to maximize the potential benefits of their research.

funds for collaborative research projects, state-of-the-art infrastructures and tissue banks, studentship and fellowships, and for the organization of an annual research symposium. The scientific discoveries of the members of the VHRN have led to great advances in the understanding of normal and pathological visual function, the development of better therapeutic strategies, the early diagnosis of diseases of the eye and the brain, visual training, rehabilitation, and in the field of visual implants.

The VHRN brings together nearly 130 principal investigators and 200 graduate students, residents, and postdoctoral trainees who are affiliated to either research axes of the VHRN, which

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