Research Scientist 3, Computational Chemistry

7 months ago

Vancouver, Canada Xenon Pharmaceuticals Inc. Full time

**Who We Are**:
**At Xenon Pharmaceuticals (NASDAQ**: XENE), we are committed to providing a brighter future for patients suffering from neurological disorders. Our employees are smart, passionate, dedicated, and driven by their incredibly important work to discover, develop, and deliver innovative medicines for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

**What We Do**:
We are advancing an exciting pipeline of neurology therapies, with a focus on commercializing novel treatments for patients in need. Building upon the positive results and compelling data from our XEN1101 Phase 2b “X-TOLE” study in adult patients with focal epilepsy, our XEN1101 epilepsy program includes multiple Phase 3 clinical trials in patients with focal onset seizures and primary generalized tonic clonic seizures. In addition, based on topline data from our XEN1101 Phase 2 “X-NOVA” clinical trial in adults with major depressive disorder (MDD), we are actively exploring the future development of XEN1101 in MDD and potentially other indications. Our pipeline also includes other early-stage research programs, and we are proud of the leading-edge science coming out of our discovery labs. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

**About the Role**:
**RESPONSIBILITIES**:

- Maintain and update/upgrade the fully automated project-specific data integration for all ongoing drug discovery projects.
- Develop internal cheminformatics, data analysis, and/or machine learning tools/platforms to support the work of medicinal chemists and/or computational chemists.
- Build company-wide ADMET models utilizing machine learning techniques.
- Assist the research IT team in building infrastructure to facilitate integration, federated access, and analysis of data generated across various drug discovery platforms.
- Provide structure-based and ligand-based computational chemistry approaches and/or machine learning support for drug discovery projects.
- Provide troubleshooting support for the tools/platforms utilized by medicinal chemists and computational chemists.
- Prepare presentation materials and effectively communicate results at internal and external meetings.
- Collaborate closely with the Computational Chemistry team, the Research IT team and the Chemistry department.
- Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.
- Other duties as assigned.

**QUALIFICATIONS**:

- PhD degree in computational chemistry or a related field.
- Proficiency in Linux environment and programming/scripting languages.
- Experience in any of the following fields: drug discovery, computational chemistry, cheminformatics, machine learning, deep learning, or generative AI.
- Proficient in Knime or capable of acquiring Knime skills.
- Preferred experience in Dotmatics and SQL scripting.
- Preferred experience in modeling software such as Schrodinger, MOE, and ICM, etc.
- Strong troubleshooting skills coupled with the ability for quick learning.
- Good presentation, oral, and written communication skills in English.
- Ability to work independently and collaboratively in a flexible team environment.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.
Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

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