Scientist, Bioconjugation Chemistry

1 month ago

Vancouver, Canada Borealis Biosciences, Inc. Full time

**Company**:
Chronic kidney diseases are a severe and growing worldwide health challenge that affects 1 in 7 people. Without effective treatments patients can experience kidney failure leading to dialysis and transplantation, a high burden to patients, families and the health care system. Despite recent advances for certain kidney disease patients, many forms of highly prevalent kidney diseases do not have effective treatments.

Borealis was founded on the premise that a convergence of scientific and translational breakthroughs will enable RNA therapeutics to address some of the largest untreated kidney diseases and beyond. Borealis builds on the success of Chinook Therapeutics, a kidney disease company with a research site in Vancouver that was acquired by Novartis in 2023 for up to $3.5 billion. The Borealis team has strong leadership and academic advisors who were central to research at Chinook, together with additional leadership in the field of RNA therapeutics. We are headquartered in Vancouver, BC, with state-of-the-art wet labs for molecular and cellular biology, in vivo pharmacology, chemistry, DMPK, bioinformatics and analytical capabilities.

**Position**:
**Responsibilities include**:

- Design, synthesis, purification, and analysis of oligonucleotides (ASO, siRNA), linkers, and protein/peptide/antibody conjugates.
- Development and implementation of new linker chemistries/spacers and bioconjugation methods for targeted drug delivery.
- Leveraging appropriate purification and analytical characterization approaches for QC and validation.
- Collaborate cross-functionally with DMPK, Biology, and In Vivo Pharmacology teams to advance Borealis Bio’s early research activities to preclinical development.
- Independently run laboratory experiments to support and advance discovery efforts.
- Design and write protocols, perform experiments, organize and analyze data, interpret results, record experiments in an electronic lab notebook, and summarize work in presentations and technical reports.
- Adhere to all laboratory safety requirements and standard operating procedures, help maintaining general laboratory functionality, including lab equipment maintenance and the ordering, and receiving of lab supplies.

**Location**:

- This is an on-site lab-based position located in Borealis’ Vancouver, BC headquarters. Much of your time will be spent in conducting wet lab work.

**Education, Experience, and Skills**:

- Ph.D. in Chemistry/Protein Biochemistry or a related science discipline with focus on bioconjugation chemistry with 1+ year of directly related industry experience; M.Sc. with minimum 5 years’ directly relevant experience; or other equivalent combination of education and experience.
- Experience in HPLC purification and analytical methods for proteins and oligonucleotides.
- Strong foundation in bioconjugation, analytical chemistry and/or chemical biology is strongly desired. Experience with oligonucleotides and targeted delivery is preferable.
- Extensive experience with different bioconjugation strategies and optimizations thereof for proteins/peptides, lipids, oligonucleotides and other biomolecules
- In-depth experience in bioconjugate purification techniques including various liquid chromatography methods (e.g. RP, IEX, SEC, HIC, affinity, FPLC) and membrane filtrations (e.g. TFF)
- Prior experience in biochemistry techniques and analytical methods such as SEC-MALs, LCMS, SPR/BLI, ELISA, SDS-PAGE, etc.
- Strong analytical mindset and chemistry problem-solving with creative thinking
- Good time management and communication skills.
- Fast learner, with great problem-solving skills to resolve potential issues that arise.
- Positive attitude and high personal and ethical standards.
- A strong team player with a passion for science and drug discovery.

**Compensation**:The annual salary range is $113,000 - 131,000 and Borealis Bio provides competitive benefits including RRSP matching, extended medical, dental, vision and a Wellness Spending Account up to $1,800 per year.
- Borealis_ is an Equal Opportunity Employer, and we prohibit discrimination or harassment of any kind_. _We are committed to fostering an environment where ALL people are welcome and supported. _We cultivate a culture of inclusion for all employees that respects their individual strengths, views, and experiences. We believe that our differences enable us to be a better team - one that makes better decisions, drives innovation, and delivers better business results_._ _Creativity and innovation flourish in an environment of openness, inclusion, and mutual respect._

  • Senior Scientist, Chemistry and Conjugation, Process and Analytical Development Expert

    1 month ago

    Vancouver, British Columbia, Canada Zymeworks Full time

    Key ResponsibilitiesWe are seeking a highly skilled Process Development Scientist to join our team in Chemistry and Conjugation.Develop and maintain a comprehensive knowledge database for Chemistry and Conjugation processes, including raw materials, scale, impurities, and data analysis.In collaboration with Contract Manufacturers, design and execute...

  • Scientist, Oligonucleotide Chemistry

    3 weeks ago

    Vancouver, Canada Borealis Biosciences, Inc. Full time

    **Company**: Chronic kidney diseases are a severe and growing worldwide health challenge that affects 1 in 7 people. Without effective treatments patients can experience kidney failure leading to dialysis and transplantation, a high burden to patients, families and the health care system. Despite recent advances for certain kidney disease patients, many...

  • Research Associate I, Bioconjugation

    4 months ago

    Vancouver, Canada Zymeworks Full time

    Job Req ID: 1263- Location: Vancouver, BC, CAN- Additional Locations: N/A- Department: Bioconjugation- Job Type: Full Time- Workplace Type: On-Site**Research Associate I, Bioconjugation**: **Company Description** **Why Work With Us** Nothing is more critical to our success than the quality of our team. The work we do is meaningful and impactful - we care...

  • Junior Scientist in Synthetic

    6 months ago

    Vancouver, Canada Pharma Inventor Inc. Full time

    **Job Postings**: Immediate open position for a Junior Scientist in Synthetic & Medicinal Chemistry areas in our Chemistry R&D site in Delta, BC. **PHARMA INVENTOR INC., **is a Vancouver-based rapidly growing drug discovery contract research & development organization. Company offers a dynamic and collaborative work environment where scientific excellence,...

  • Associate Scientist, Chemistry

    6 months ago

    Vancouver, Canada adMare BioInnovations Full time

    **About adMare BioInnovations**: With a strong track record of globally competitive scientific discovery, Canadian life sciences is primed to lead the world. To make this a reality, adMare BioInnovations uses its scientific and commercial expertise, specialized R&D infrastructure, and seed capital to build strong life sciences companies, robust ecosystems,...

  • Senior Scientist

    1 week ago

    Vancouver, British Columbia, Canada Borealis Biosciences, Inc. Full time

    Borealis Biosciences, Inc. is a cutting-edge biotech company pioneering RNA therapeutics for kidney disease and beyond.We are seeking a highly skilled Senior Scientist to join our dynamic chemistry group in Vancouver, BC.The ideal candidate will have extensive hands-on experience in oligonucleotide chemistry techniques, including solid-phase synthesis,...

  • Associate Scientist/scientist Radiochemistry and

    6 months ago

    Vancouver, Canada Abdera Therapeutics Full time

    **Who we are** Abdera Therapeutics Inc. is a precision oncology company developing next-generation targeted radiation therapies - one of the most cutting-edge and highly promising areas of drug development. The company is built on a proprietary modular technology platform optimized for the delivery of radioisotopes to selectively destroy tumor cells while...

  • Senior Scientist, Chemistry and Conjugation, Process and Analytical Development

    6 months ago

    Vancouver, Canada Zymeworks Full time

    Key Responsibilities Maintain process knowledge database for Chemistry and Conjugation including related raw materials, scale, impurities and data analysis using statistical or other methods. In collaboration with CMO partners, conceive and devise experiments to test process changes and analyze the results through statistical means or otherwise. A...

  • Senior Scientist, Cell Biology Specialist

    4 weeks ago

    Vancouver, British Columbia, Canada Zymeworks Full time

    At Zymeworks, we are committed to discovering and developing innovative cancer therapies. As a Senior Scientist, Cell Biology Specialist, you will play a crucial role in our team's success.Key ResponsibilitiesYou will oversee the design, coordination, execution, and analysis of in vitro pharmacology experiments for the screening and progression of novel...

  • Associate Scientist/scientist Radiochemistry and

    6 months ago

    Vancouver, Canada Abdera Therapeutics Full time

    **Who we are** Abdera Therapeutics Inc. is a precision oncology company developing next-generation targeted radiation therapies - one of the most cutting-edge and highly promising areas of drug development. The company is built on a proprietary modular technology platform optimized for the delivery of radioisotopes to selectively destroy tumor cells while...

  • Protein Scientist, Biology

    2 months ago

    Vancouver, Canada Borealis Biosciences, Inc. Full time

    **Company**: Chronic kidney diseases are a severe and growing worldwide health challenge that affects 1 in 7 people. Without effective treatments patients can experience kidney failure leading to dialysis and transplantation, a high burden to patients, families and the health care system. Despite recent advances for certain kidney disease patients, many...

  • Senior ADC Discovery Expert

    3 weeks ago

    Vancouver, British Columbia, Canada AbCellera Full time

    About AbCelleraAbCellera is pioneering a new era of antibody-based medicine discovery. Leveraging innovative solutions at every step, from custom antigen preparation and immunizations to high-throughput imaging, genomics, computation, machine learning, and laboratory automation, we're revolutionizing how scientists can explore natural antibody diversity and...

  • Associate Scientist, in Vitro Biology

    5 months ago

    Vancouver, Canada Zymeworks Full time

    Job Req ID: 1126- Location: Vancouver, BC, CAN- Additional Locations: N/A- Department: In Vitro Biology- Job Type: Full Time- Workplace Type: On-Site**Associate Scientist, In Vitro Biology**: **Company Description** **Why Work With Us** Nothing is more critical to our success than the quality of our team. The work we do is meaningful and impactful - we...

  • Bioanalytical Scientist

    6 months ago

    Vancouver, Canada Pharma Inventor Inc. Full time

    **BIOANALYTICAL SCIENTIST** **Job Postings**: Applications are welcome for a suitable Bioanalytical Scientist position in our Chemistry R&D site in Vancouver, B.C. Canada **PHARMA INVENTOR INC., **is a Vancouver based rapidly growing contract Chemistry Research & Development organization. Company offers a dynamic and collaborative work environment where...

  • Process Development Associate

    6 months ago

    Vancouver, Canada STEMCELL Technologies Full time

    **Job Description Summary**: Are you looking to use your critical thinking skills to solve complex problems at the interface of organic chemistry, material science, and chemical engineering? Grow your biotechnology career as a Process Development Associate at STEMCELL Technologies, Canada's largest biotechnology company! As a Process Development Associate,...

  • Research Scientist, Chemistry

    6 months ago

    Vancouver, Canada Biofine International Inc Full time

    Education: - Expérience: **Education**: - Master's degree **Tasks**: - Analyze, synthesize, purify, modify and characterize chemical or biochemical compounds - Conduct research into the synthesis and properties of chemical compounds and the mechanisms of chemical reactions **Analytical techniques**: - Chromatography - Physical separation...

  • Chemistry Instructor

    3 months ago

    Vancouver, Canada STEM MONTESSORI ACADEMY OF CANADA Full time

    Are you a science enthusiast interested in creating meaningful educational opportunities as a Biochemistry Instructor? We have a teaching opportunity in the field of Chemistry, educating young and thriving scientists. The future of science could be in your hands! **We are in search of a virtual Chemistry Instructor who has**: - 1 or more years of...

  • Associate Scientist/scientist, Analytical Chemistry

    6 months ago

    Vancouver, Canada Abdera Therapeutics Full time

    **Who we are** Abdera Therapeutics Inc. is a precision oncology company developing next-generation targeted radiation therapies - one of the most cutting-edge and highly promising areas of drug development. The company is built on a proprietary modular technology platform optimized for the delivery of radioisotopes to selectively destroy tumor cells while...

  • Senior Conjugate Development Scientist

    3 weeks ago

    Vancouver, British Columbia, Canada AbCellera Biologics Full time

    Breakthrough in Antibody Drug DiscoveryA competitive salary of $180,000 - $250,000 per year, along with comprehensive benefits, and a dynamic work environment make this role at AbCellera Biologics an attractive opportunity for highly motivated scientists.About the JobIn this pivotal position, you will lead the development of innovative antibody drug...

  • Process Development Associate

    6 months ago

    Vancouver, Canada STEMCELL Technologies Full time

    **Job Description Summary**: Are you ready to kick start your career in the exciting, fast-paced Canadian biotechnology industry? If you are looking to use your critical thinking skills to solve complex problems at the interface of organic chemistry, material science, and chemical engineering, this might be the job for you! As a Process Development...