Technical Officer, Cell Line Development

Tenure: Term Duration: Two (2) years  Language Requirements: French Work arrangements: Due to the nature of the work and operational requirements, this position will require full-time physical presence at the NRC work location identified.Discover the possible Anything is possible at the NRC, named in 2025 one of Canada’s Top Employers for Young People, Top Employer in the National Capital Region and Forbes Canada’s Best Employers As Canada’s leading research and technology organization, our world-renowned research pushes the boundaries of science and engineering to make the impossible, possible. Every day we explore new ideas through innovative research and help companies discover possibilities that impact Canada’s future and the world. At the NRC, you’ll also discover new possibilities. Our supportive workplace fosters a culture of creativity, welcoming fresh perspectives and innovation at all levels. We value teamwork. You’ll collaborate across multiple fields and with the brightest minds to find creative solutions. Most importantly, you’ll discover what’s possible within you as you grow, make valuable contributions and progress in your professional journey. From ground-breaking discoveries to a life-changing career, discover your possible at the NRC. The role We are looking for a Technical Officer to support the Cell Line Development team in our Human Health Therapeutics Research Centre. The incumbent would be someone who shares our core values of Integrity, Excellence, Respect and Creativity. The Human Health Therapeutics Research Center (HHT) has a mandate to support the country's economic development through healthcare innovations, including novel therapies. The research center has a strong track record of collaborations with industry and is a key player in the prosperity of small and medium-sized enterprises (SMEs). With its primary sector of activity being the biopharmaceutical industry, the portfolio targets Canadian SMEs developing therapeutic products, biologics, or vaccines to address human health needs. As part of the Cell Line Development team, the Technical Officer will support NRC, other government departments and industry research activities through technical assistance and facility maintenance at our Royalmount facility in Montreal. The incumbent will be part of a multidisciplinary team, providing essential support for ongoing projects and programs involving our industry partners and other government departments and agencies in the area of biotechnology. The Technical Officer in Cell Line Development plays a pivotal role in the creation and optimization of mammalian cell lines used for biologics production. This position bridges molecular biology, cell culture, and bioprocess engineering to ensure robust, high-yielding cell lines that meet regulatory and commercial standards. The key responsibilities of the technical officer are the following: Cell Line Engineering: Design and execute strategies for transfection, selection, and cloning of mammalian cells (, CHO, HEK293) to express therapeutic proteins, monoclonal antibodies, or other biologics. Clone Screening & Characterization: Use high-throughput screening tools (, ELISA, Biolayer Interferometry (BLI), flow cytometry) to identify top-performing clones based on productivity, growth kinetics, and product quality. Genetic Stability & Expression Analysis: Assess long-term stability of cell lines and confirm transgene integration using techniques like ddPCR, Southern blotting, and sequencing. Process Development Interface: Collaborate with upstream and downstream teams to ensure cell lines are compatible with scalable bioreactor processes and downstream purification. Documentation & Compliance: Maintain detailed records of experimental design, results, and protocols in accordance with internal quality level and regulatory guidelines. Technology Innovation: Evaluate and implement emerging technologies (, CRISPR, single-cell analysis, automation platforms) to enhance cell line development workflows. Screening criteria Applicants must demonstrate within the content of their application that they meet the following screening criteria in order to be given further consideration as candidates: Education Bachelor of Science degree () in biotechnology, biochemistry or a field related to the position. A Master’s graduate degree () in biotechnology, biochemistry or a field related to the position would be considered an asset. For information on certificates and diplomas issued abroad, please see Degree equivalencyExperience Extensive* experience performing experiments in molecular biology such as PCR, plasmid constructs, and plasmid maxipreps. Extensive* experience performing experiments with protein expression systems. Extensive* experience performing cell culture under aseptic conditions. Significant** experience with mammalian cell line development platforms and analytical tools for protein production. Significant** experience troubleshooting and optimizing experimental conditions. Significant** experience performing experiments and technical duties following standard operating protocols related to production process. Significant experience documenting and maintaining detailed records of experimental design, protocols, results, and conclusions.  The following experience criteria would be considered assets: Experience operating and maintaining cell culture equipment. Experience in protein purification and analytic. * Extensive experience is defined as seven (7) years of experience or more.** Significant experience is defined as two (2) to six (6) years of experience.Condition of employment Must be able to work in a laboratory environment in a Biological Safety Cabinet (BSC). Reliability Status For a Reliability Status, verification of background information over a period of 5 years is required. Language requirements French Information on language requirements and self-assessment testsAssessment criteria Candidates will be assessed on the basis of the following criteria: Technical competencies Knowledge of standard molecular biology techniques (PCR, plasmid production, gene fragment subcloning) Knowledge of protein production and expression systems, especially mammalian cell expression Knowledge of cell culture and working under aseptic conditions Knowledge of occupational health and safety best practices required to create and maintain a safe and healthy work environment. Knowledge of regulatory requirements for traceability and characterization of cell lines. Behavioural competencies Research Technician/Technologist - Communication (Level 2) Research Technician/Technologist - Creative thinking (Level 2) Research Technician/Technologist - Results orientation (Level 2) Research Technician/Technologist - Teamwork (Level 2) Competency Profile(s) For this position, the NRC will evaluate candidates using the following competency profile: Research Technician/Technologist View all competency profilesCompensation From $66,126 to $91,012 per annum.  NRC employees enjoy a wide-range of competitive benefits including a robust pension plan, comprehensive health and dental coverage, disability and life insurance, office closure at the end of December, and additional supports to enhance your well-being throughout your career and beyond.