Research Associate, Process Development

4 weeks ago


Montreal, Canada 35Pharma Inc Full time

The role of the research associate is to participate in the development of manufacturing processes for the expression and/or purification of therapeutic recombinant proteins. Processes are developed as part of scaling up and manufacturing according to Good Manufacturing Practices (GMP). Another important part of this role is the rapid production of recombinant proteins using the company's laboratory platform for the selection of candidate proteins. The incumbent will use defined scientific practices to develop and/or use protein production procedures to support technology transfer to contract manufacturing organizations. Other responsibilities include participating analytical results interpretation and in the maintenance of laboratory equipment.This is a full-time position reporting to the Director of Process Development and is based in Montreal, QC, Canada.Functions and responsibilities:Produce recombinant candidate proteins from the CHO cell line system platform using shaker flasks, bioreactors (WAVE), clarification and filtration.Perform mammalian cell culture activities such as cell maintenance, transfection for stable protein expression and isolation of cellular pools using the CHO cell line.Participate in the development of robust upstream manufacturing processes on candidate recombinant proteins.From time to time perform platform-based small scale protein purification.Analyze results obtained from the Analytical group on routine analyses.Responsible for the analysis and documentation of obtained experimental data (electronic laboratory notebook and files).Prepare protocols and reports on experiments performed.Responsible for the maintenance of laboratory equipment.Provide technical and scientific support during the development process.Participate in technology transfer activities.Use a quality-by-design (QbD) approach during all process development phases.Qualifications:At least a Bachelor of Science (B.Sc.) degree in biochemistry, biotechnology, or equivalent.A minimum of 2 years of experience in stable protein expression, upstream process development and/or manufacture of recombinant proteins or relevant experience in biotechnology or biopharmaceutical industry.Experience in mammalian cell culture and recombinant protein expression systems.Meticulous laboratory practice with good aseptic technique.Experience at analyzing and presenting experimental cell culture resultsKnowledge of downstream process technologies and protein purification is an asset.Ability to conduct experiments independently.Ability to work in multifunctional teams and in a dynamic environment.Experience in problem solving.Effective communicator in writing and speaking.Knowledge of Good Manufacturing Practice (GMP) is an asset.Contact:Please send your CV and cover letter outlining your motivation and relevant experience for the role to careers@hypermabs.com quoting “35Pharma Posting RAPD0926” in the subject line – we are looking forward to hearing from youSubscribeTo receive our press releases, please subscribe to our mailing list35Pharma is a biopharmaceutical company focused on designing and developing innovative biologics for diseases with high unmet medical need.750 St Laurent Boulevard, Suite 101Montreal, QC H2Y 2Z4Canada50 Milk St.,Boston, MA 02109United StatesIf you have any questions regarding our privacy protection practices, please contact our Privacy Officer at privacy@35pharma.com and view our Privacy Policy here. #J-18808-Ljbffr



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