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Research Scientist 1, Cmc, Formulations
4 months ago
**Who We Are**:
**At Xenon Pharmaceuticals (NASDAQ**: XENE), we are committed to providing a brighter future for patients suffering from neurological disorders. Our employees are smart, passionate, dedicated, and driven by their incredibly important work to discover, develop, and deliver innovative medicines for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.
**What We Do**:
We are advancing an exciting pipeline of neurology-focused therapies, with a focus on commercializing novel treatments for epilepsy. Building upon the positive results and compelling data from our XEN1101 Phase 2b “X-TOLE” study in adult patients with focal epilepsy, our XEN1101 Phase 3 program includes studies in adult patients with focal onset seizures and primary generalized tonic clonic seizures. In addition, XEN1101 is being evaluated as a treatment for major depressive disorder in both a company-sponsored Phase 2 clinical trial, as well as an investigator-led proof-of-concept study. Xenon's proprietary, pediatric formulation of ezogabine, XEN496, is being studied in a Phase 3 clinical trial in young patients with KCNQ2-DEE, a rare and severe form of childhood epilepsy. We are also proud of the leading-edge science coming out of our discovery labs, where many innovative, early-stage research programs are underway. In addition to these proprietary programs, our pipeline includes clinical-stage partnered programs with valued collaborators. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.
**About the Role**:
**RESPONSIBILITIES**:
- Collaborate with colleagues in the Discovery group to characterize the physicochemical properties of NCEs and develop suitable formulations for evaluation in animal models.
- Develop fit-for-purpose analytical methods to support characterization of new compounds and formulation prototypes.
- Conduct, execute, and report formulation-related experiments (written reports and presentation in meetings).
- Organize and file internal data, protocols, and reports.
- Keep up to date and detailed records of experiments and data analysis within an Electronic Lab Notebook system. Ensure experiments are counter-signed on a monthly basis.
- Ensure the laboratory environment safe and well-organized; follow and keep up to date Health & Safety policies.
- Recruit, lead, direct, develop, coach, and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices.
- Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.
- Other duties as assigned.
**QUALIFICATIONS**:
- PhD in Chemistry or Pharmaceutical sciences is strongly preferred, with a minimum of 1-2 years’ experience developing formulations for assessment in preclinical models is preferred.
- Prior hands-on experience with various analytical techniques, such as HPLC, is preferred.
- Excellent written and oral communication skills, including the ability to communicate to all audience types (scientific, non-scientific).
- Excellent attention to detail and commitment to providing accurate, high-quality work.
- Good organizational skills and the ability to manage multiple competing priorities.
- Strong interpersonal and team skills to work both independently and collaboratively as part of a multidisciplinary team.
