Research Assistant

2 months ago

Montréal QC, Canada Lady Davis Institute Full time

**Description du poste (english version below)**:
L'objectif de l'étude MIRAE est de faciliter la recherche sur les toxicité immunologiques liés à l'immunité (immune-related adverse events, irAEs) secondaires à l'immunothérapie du cancer avec des inhibiteurs de points de contrôle immunitaire (immune checkpoint inhibitors, ICI), et les maladies auto-immunes et auto-inflammatoires traditionnelles. L'immunothérapie fait référence à divers traitements qui renforcent la capacité des cellules immunitaires à rechercher et à détruire les cellules cancéreuses. Ces traitements peuvent conduire à des rémissions remarquables du cancer, mais leur utilisation est parfois limitée par d'importantes toxicités auto-immunes ou irAEs. L'objectif de l'étude MIRAE est d'identifier les prédicteurs et les mécanismes associés aux irAEs, de développer des stratégies de traitement optimales pour les irAEs, et d'acquérir de nouvelles connaissances sur les maladies auto-immunes et auto-inflammatoires primaires.

L'équipe MIRAE est un groupe multidisciplinaire et multi-institutionnel de chercheurs cliniques et translationnels dans les domaines de l'oncologie et de l'immunologie. Actuellement, l'étude MIRAE utilise des technologies multiomiques de séquençage de l’ARN sur cellule unique et d'autres tests à haut débit pour établir le profil des cellules immunitaires dans le sang et les lésions tissulaires des patients cancéreux traités par ICI, ainsi que pour identifier les facteurs immunitaires solubles cliniquement pertinents dans leur plasma.

**Responsabilités et tâches**:
Dans le cadre de ses fonctions, l'assistant de recherche aura les responsabilités suivantes:
1. Identifier les participants éligibles à l'étude MIRAE parmi les patients atteints de cancer et traités par ICI au JGH.

2. Obtenir le consentement éclairé pour la mise en banque de spécimens biologiques, y compris le sang et les tissus, et l'accès aux données cliniques des patients conformément aux lignes directrices des BPC de Santé Canada.

3. Traitement du sang pour la séparation du plasma, l'isolement des PBMCs, le stockage ultérieur et la documentation dans la base de données ATiM.

4. Préparation des échantillons pour les différents projets MIRAE (par exemple, isolement de l'ADNg et de l'ARN, essais de stimulation des PBMCs).

6. Collecte et analyse des paramètres cliniques pertinents.

**Qualifications**:
1. Être titulaires au minimum d'un baccalauréat en sciences (BSc).

2. Avoir 2 ans d'expérience dans un laboratoire de recherche.

3. Une expérience du travail dans des conditions BSL-2, de la culture de tissus et de cellules et des techniques de base de la biologie moléculaire (par exemple, PCR/RT-PCR, isolement de l'ADN/ARN) est souhaitée.

4. Excellente connaissance de l'anglais et connaissance pratique du français.

6. Une expérience des systèmes de saisie électronique des données et des logiciels de biobanques tels que RedCap et ATiM est un atout mais n'est pas nécessaire.

**Le comité consultatif scientifique de MIRAE est composé de**:
Dr. Marie Hudson (Directrice, JGH)

Dr Wilson Miller (JGH)

Dr Khashayar Esfahani (Hôpital St. Mary's/HGJ)

Dr Nathalie Johnson (JGH)

Dr Sonia del Rincón (LDI)

Dr Réjean Lapointe (CRCHUM)

Manuel Flores (coordinateur du MIRAE) et soumises par voie électronique à l'adresse suivante:
1. Curriculum vitae.

2. Lettre de motivation.

3. Références, noms et coordonnées de deux personnes de référence.

Rémunération : Compétitive

Type d'emploi : Temps plein - horaire du lundi au vendredi 35 heures par semaine

1. En présentiel

2. Date de début : Immédiatement.

3. Date de clôture : Le poste restera ouvert jusqu'à ce qu'il soit rempli.

Avantages sociaux:

- 20 jours de vacances;
- Congés de maladie : 9,6 jours par an.
- Jours fériés: 13 jours par an
- Régime d'assurance collective (Croix Bleue) qui comprend couverture pour soins de santé et dentaires : médicaments d’ordonnance, procédures de radiologie, tests de laboratoire, soins de la vue, soins médicaux d'urgence encourus à l'extérieur du Canada, assurance-vie collective pour mort accidentelle et démembrement, maladies graves et invalidité de longue durée.
- Régime de retraite (RREGOP

**Position Description**:
The Lady Davis Institute (LDI) is seeking applicants for a full-time research assistant position in the Montreal Immune-Related Adverse Events (MIRAE) team.

The purpose of the MIRAE study is to facilitate research on immune-related adverse events (irAEs) secondary to immunotherapy with immune checkpoint inhibitors (ICI), and traditional autoimmune and autoinflammatory diseases. Immunotherapy refers to various treatments that enhance the power of immune cells to seek out and destroy cancer cells. These treatments can lead to remarkable cancer remissions, but their use is sometimes limited by significant autoimmune toxicities or irAEs. The goal of the MIRAE study is

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