![Sygnature Discovery Limited](https://media.trabajo.org/img/noimg.jpg)
director, medicinal chemistry
2 weeks ago
NuChem Sciences, une compagnie Sygnature Discovery est une organisation de recherche contractuelle de découverte de médicaments intégrée de premier plan basée au Royaume-Uni et au Canada avec son siège social à Nottingham et des installations supplémentaires à Alderley Park, Macclesfield, Glasgow, Montréal et Québec. Son personnel de plus de 1 000 personnes, dont 900 scientifiques, s'associe à l'industrie pharmaceutique mondiale, de biotechnologie et des organisations BNL.
Depuis 2004, Sygnature Discovery a livré plus de 40 nouveaux composés précliniques et 22 composés cliniques, avec ses scientifiques nommés sur plus de 170 brevets. Les domaines d'expertise thérapeutiques comprennent l'oncologie, l'inflammation et l'immunologie, les neurosciences, les maladies métaboliques, les maladies infectieuses, les maladies fibrotiques et plus encore. Pour en savoir plus, veuillez visiter et
Concernant le rôle
Nuchem Sciences est présentement à la recherche d'un(e) candidat(e) pour occuper un poste de Directeur(trice), Chimie médicinale à son centre de recherche situé à Ville Saint-Laurent. L'entreprise offre une variété de services préclinique en support à l'industrie pharmaceutique et biotechnologique afin d'aider à identifier et optimiser les cibles pour la découverte et le développement de nouveaux médicaments.
RESPONSABILITÉS:
Planifier et exécuter des stratégies de chimie médicinale pour l'identification de candidats précliniques potentiels de haute qualité;
Diriger des programmes de découverte du médicament en étroite collaboration avec les équipes internes et externes, y compris des CRO;
Mettre en œuvre et conduire des stratégies innovantes de découverte de médicaments en utilisant une expertise approfondie dans la conception de voies de chimie médicinale et de chimie synthétique, grâce à une connaissance approfondie du DMPK, de la pharmacologie et de la toxicologie;
Appliquer des principes modernes de conception de médicaments pour résoudre les problèmes de chimie médicinale pertinents pour le projet;
Utiliser des méthodologies et des techniques synthétiques de pointe pour concevoir des synthèses de composés cibles pour les séries chimiques existantes et les nouvelles séries;
Atteindre les objectifs du projet en lien avec ceux du client ;
Gérer des chefs d'équipe internes et des équipes de scientifiques de synthèse ;
QUALIFICATIONS:
·Doctorat en chimie organique de synthèse ou chimie médicinale avec plus de 10 ans d'expérience dans la découverte de médicaments dans un environnement pharmaceutique et/ou biotechnologique;
·Expert en chimie médicinale avec une excellente compréhension de la biologie, de la pharmacologie, du DMPK et la capacité d'intégrer ces disciplines pour assurer une progression réussie du projet;
·Forte expérience en chimie médicinale, appuyée de succès antérieurs dans l'avancement de projets de découverte de médicaments jusqu'à la nomination de candidats cliniques, un atout important;
·Expérience en conception structurelle et en gestion de projet ;
·Solide connaissance et expérience des méthodes de synthèse actuelles ;
·Excellentes compétences en rédaction, présentation et communication (orales et écrites) ;
·Excellentes compétences en leadership et expérience de travail dans un environnement multidisciplinaire dynamique;
·Capacité démontrée à dépanner et à résoudre les problèmes de manière créative;
·Bonne maîtrise de Microsoft Office (Word, Excel et PowerPoint) ;
·Les candidats doivent être admissibles à travailler au Canada (citoyen canadien, résident permanent ou permis de travail).
RÉMUNÉRATION ET AVANTAGES SOCIAUX:
Salaire:
·Compétitif et selon l'expérience
Prime :
·Plan de boni annuel
Avantages :
·Soins de santé et dentaire;
·Assurance invalidité;
·Assurance-vie;
·REER avec contribution jumelée de l'employeur;
·Programme de télé-médecine;
·Code vestimentaire décontracté;
·Horaire flexible;
·Congés personnels;
·Stationnement sur place gratuit;
·Formation continue;
·Développement professionnel.
Horaire :
·Lundi au vendredi
Background
NuChem Sciences, a Sygnature Discovery business is a world-leading integrated drug discovery Contract Research Organisation based in the UKand Canada with its headquarters in Nottingham and additional facilities in Alderley Park, Macclesfield, Glasgow, Montreal and Quebec City. Its staff of over 1,000, which includes 900 scientists, partners with global pharma, biotech and NFP organisations.
Since 2004, Sygnature Discovery has delivered over 40 novel pre-clinical and 22 clinical compounds, with its scientists named on over 170 patents. Therapeutic areas of expertise include oncology, inflammation and immunology, neuroscience, metabolic diseases, infectious diseases, fibrotic diseases and more. To find out more, please visit and
About the role
NuChem Sciences is currently looking for a candidate for the position of Director, Medicinal Chemistry at its research center located in Ville Saint-Laurent. The company provides a variety of preclinical services to the pharmaceutical and biotechnology industry helping them in their drug discovery and development.
RESPONSIBILITIES:
Implement and execute medicinal chemistry strategies to deliver potential high quality preclinical candidates;
Lead drug discovery programs in effective collaboration with internal and external teams, including CROs;
Implement and drive innovative drug discovery strategies utilizing deep expertise across medicinal chemistry and synthetic chemistry route design, through comprehensive knowledge of DMPK, pharmacology, and toxicology;
Apply modern drug design principles to solve medicinal chemistry problems relevant to the project;
· Utilize cutting-edge synthetic methodologies and techniques to design syntheses of target compounds within existing and novel chemical series ;
· Achieve the project objectives in line with those of the client;
· Manage internal team leaders and teams of medicinal and synthetic chemists;
REQUIREMENTS:
·PhD in synthetic organic or medicinal chemistry with 10+ years of drug discovery experience in a pharmaceutical and/or biotechnology environment;
·Medicinal Chemistry expert with excellent understanding of biology, pharmacology, DMPK and ability to integrate these disciplines toward successful project progression;
·Demonstrated track record in medicinal chemistry as evidenced by successful advancement of drug discovery projects to clinical candidate nomination a strong asset;
·Experience in structure-based drug design;
·Project management experience;
·Strong knowledge of and experience in current synthetic methodologies;
· Excellent written and oral, presentation and communication skills;
· Great leadership skills and experience working in dynamic multidisciplinary environment
· Demonstrated ability to troubleshoot and creatively in solving problems;
· Proficiency in Microsoft Office (Word, Excel and PowerPoint);
· Applicants must be eligible to work in Canada (Canadian citizen, permanent resident or work permit).
COMPENSATION AND BENEFITS:
Salary:
·Competitive and based on experience.
Additional pay:
Annual bonus incentive plan.
Benefits:
·Full time permanent position;
Health and dental care insurance plan;
Short- and long-term disability insurance;
Life insurance;
RRSP employer's matching program;
Casual dress code;
Flexible schedule;
On-site free parking;
Continuing education;
Career development.
Schedule:
Monday to Friday.
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