Pension Associate Intern

3 weeks ago

Toronto ON, Canada University Health Network Full time

The University Health Network, where “above all else the needs of patients come first”, encompassesToronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute and the Michener Institute of Education. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of ground breaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.
Site: Princess Margaret Cancer Centre
Department of Surgical Oncology
Work Model: On-Site
compensation policy.
Shifts: Monday - Friday
Temporary Full-Time (12 months)
To accomplish this, we systematically apply high-content, multi-gene targeting CRISPR screens to patient-derived humanized models of cancer to identify strategies for improving response to therapy. We are seeking a highly motivated and accomplished PhD-level Research Associate to lead our dynamic team focused on functional genomic strategies for improving surgically delivered cell therapies targeting genitourinary malignancies. The successful candidate will not only drive research efforts but also play a crucial role in supervising and mentoring PhD students and post-doctoral researchers. Lead and manage a team of PhD students and post-docs engaged in functional genomics research, providing guidance, mentorship, and support to ensure project success.
Design and execute experiments leveraging high-content single-cell genomic and spatial CRISPR screens for engineering of novel cell-based therapies ( e.g. CAR-T cells) against genitourinary cancers.
Establish standard operating procedures for the generation and characterization of CD34+ hematopoietic stem cell derived humanized mice bearing patient derived orthotopic xenografts (in collaboration with animal facility).
Prepare research findings for publication in peer-reviewed journals and present results at scientific conferences and internal meetings.
Maintain accurate records of experimental procedures, data analysis, and research outcomes, ensuring compliance with regulatory standards and best practices.
Qualifications PhD in Molecular Biology, Genetics, Genomics, Cell Biology, or a related field, with a strong publication record demonstrating expertise in functional genomics research.
5+ years of research experience with a PhD in molecular biology or related field.
Proficiency in molecular biology techniques, including DNA/RNA isolation, PCR, cloning, CRISPR-Cas based gene editing, single-cell genomics.
Demonstrated expertise in cell culture techniques, preferably with experience working with primary cells or stem cells.
Experience with next-generation sequencing (NGS) platforms and associated data analysis tools ( e.g., R, Python, Bioconductor) is highly desirable.
Strong analytical and problem-solving skills, with the ability to critically evaluate complex genomic datasets and draw meaningful conclusions.
Highly organized and detail-oriented, with the ability to manage multiple projects simultaneously.
Proven leadership and mentoring abilities, with experience supervising and managing PhD students and post-doctoral researchers.
Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP )
A flexible work environment
Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)
All UHN Employees are required to be fully vaccinated with a COVID-19 vaccine series, approved by Health Canada or the World Health Organization, as a condition of hire. Proof of COVID-19 vaccination will be required. Should you be the successful candidate, you will be required to comply with UHN’s mandatory Vaccination Policy that is in effect.
Requests for accommodation can be made at any stage of the recruitment process.

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