Scientist – RNA Delivery

2 weeks ago

Montreal, Quebec, Canada e5a1a169-43ce-4944-936d-786db906f153 Full time $120,000 - $180,000 per year

Company Profile:
New stealth-mode mRNA therapeutics startup is harnessing MIT-grown chemistry and machine learning to unlock mRNA's therapeutic potential. The Company is unlocking the potential to treat diseases currently unattainable with standard approaches. The novel technology harnesses the power of chemistry coupled to machine learning to impact drug discovery and development for rare genetic diseases, vaccines and cancer.

Position Summary:
We are seeking a highly skilled and motivated Cellular Delivery Scientist to join our growing research and development team in Montreal, Q
uebec. The successful candidate will be responsible for late-stage development, formulation, and biological testing of modified mRNA molecules to support the discovery and development of the Company's next-generation therapeutics. This includes LNP formulation, biophysical characterization, cellular assays and cellular target development. This role is essential to advancing our modified mRNA-based therapeutic platforms and technologies.

Qualifications:

  • Ph.D. or M.Sc. in Cell Biology, Molecular Biology, Genetics, or a related field with a focus on RNA biology.
  • 3+ years of laboratory experience working with RNA, preferably in an academic or industry setting.
  • Proficiency in analysis and handling of RNA under RNase-free conditions, and/or other biologic molecules.
  • Experience with generative lipid nanoparticles, emulsions, exosomes or other encapsulation technology.
  • Experience with RNA analytical methods (e.g., Fragment analyzer, GE, LC, Nanodrop).
  • Experience with cell culture, transfection techniques, and gene expression analysis.
  • Strong data analysis and troubleshooting skills.
  • Experience with scientific software tools (e.g., GraphPad Prism, Excel, image analysis software, etc).
  • Fluency in French and English languages
  • Excellent written and verbal communication skills.
  • Proven ability to work independently

Preferred Qualifications:

  • Experience with mRNA therapeutics, RNA interference (siRNA/shRNA), or alternative delivery approaches.
  • Experience with nanoparticle characterization methods including dynamic light scattering, zeta-sizer and encapsulation efficiency measurements
  • Experience in regulatory documentation or writing technical reports in a GMP/GxP environment.

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