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Postdoctoral Scientist – Translational Biology

2 weeks ago

Montreal, Quebec, Canada e5a1a169-43ce-4944-936d-786db906f153 Full time $80,000 - $120,000 per year

Job Title:
Postdoctoral Scientist – Translational Biology

Location:
Montreal, QC Canada

Job Type:
Full-Time

Industry:
Biotechnology / Life Sciences / Pharmaceutical

Experience Level:
Intermediate to Senior

Company Profile:

New stealth-mode mRNA therapeutics startup is harnessing MIT-grown chemistry and machine learning to unlock mRNA's therapeutic potential. The Company is unlocking the potential to treat diseases currently unattainable with standard approaches. The novel technology harnesses the power of chemistry coupled to machine learning to impact drug discovery and development for rare genetic diseases, vaccines and cancer.

Position Summary:

We are seeking a highly skilled and motivated Postdoctoral Scientist in Translational Cell Biology to join our growing research and development team in Montreal, Q
uebec. The successful candidate will be responsible for late-stage development, biological testing, and in vivo efficacy studies for modified mRNA molecules to support the development of the Company's next-generation therapeutics. This includes cell-based assays, flow cytometry, immunoassay development, ADCC assays, in vivo tissue analysis and microscopy techniques. This role is essential to advancing our modified mRNA-based therapeutic platforms and technologies.

Key Responsibilities:

  • Develop and optimize cell-based assays involving mRNA, flow cytometry, ex vivo analysis and in vivo study designs
  • Maintain accurate and detailed laboratory records and ensure data integrity.
  • Analyze and interpret experimental data, draw meaningful conclusions, and present findings to internal teams.
  • Collaborate with multidisciplinary teams including molecular biology, chemistry, and machine learning.
  • Stay up to date with advancements in RNA biology, nucleic acid therapeutics, and related technologies.
  • Ability to work independently in a dynamic work environment

Qualifications:

  • Ph.D. or M.Sc. in Cell Biology, Molecular Biology, Genetics, or a related field with a focus on RNA biology.
  • 3+ years of laboratory experience working with RNA, preferably in an academic or industry setting.
  • Must be eligible for Mitacs funding
  • Experience with in vivo study design and coordination of experiments
  • Experience with confocal microscopy, fluorescence approaches to tissue analysis Experience with cell culture, transfection techniques, and gene expression analysis.
  • Proficiency in analysis and handling of RNA under RNase-free conditions, and/or other biologic molecules.
  • Strong data analysis and troubleshooting skills.
  • Experience with scientific software tools (e.g., GraphPad Prism, FloJo, Excel, image analysis software, etc).
  • Fluency in French and English languages
  • Excellent written and verbal communication skills.
  • Proven ability to work independently.

Preferred Qualifications:

  • Experience with mRNA therapeutics, RNA interference (siRNA/shRNA), or alternative delivery systems.
  • Experience working in a cross-functional work environment
  • Analysis of biologics and readouts from animal tissues or cell lines
  • Experience in regulatory documentation or writing technical reports in a GMP/GxP environment.

What We Offer:

  • Opportunities for professional growth and development.
  • Collaborative and innovative research environment.
  • Contribution to cutting-edge therapeutic development in RNA science.

To Apply:

Please submit your CV, a cover letter, and a brief summary of relevant RNA-related project experience to