Principal Investigators in Biomedical Discovery Research 2025

The Lunenfeld-Tanenbaum Research Institute (LTRI) of Sinai Health, a University of Toronto-affiliated research centre, is seeking two (2) emerging leaders in the broad area of Biomedical Discovery Research. The appointments will be for Full-Time Principal Investigators, rank equivalent to Assistant Professor, with the anticipated starting date of September 1, 2026, or a date to be mutually agreed upon.  The LTRI provides competitive start-up packages and salaries, commensurate with experience and qualifications.

We are seeking two (2) new colleagues who will develop innovative, outstanding and independent research programs, with either a wet lab or combined computational and wet lab focus, in of the following topics:

(i) Systems, Cellular, Chemical or Molecular Biology of human health or disease (broad biomedical sciences).  Examples of topics of interest include the investigation of fundamental biological processes at the molecular, cell or organismal levels; disease modeling and pathophysiology; therapeutic discovery and development. We welcome applications in all areas of relevance to human health and especially encourage applications in the areas of strategic focus for our institution. Those include oncology; reproduction, embryogenesis & pregnancy; infectious and inflammatory diseases; metabolic disorders and neurodegeneration. Research approaches may include the application of hypothesis-driven studies; the generation, analysis and modeling of large biological datasets; or the engineering of molecules (small or large), proteins, cells or tissues that have research or therapeutic utility.

(ii) One position will be reserved for candidates who focus on stem cell biology and tissue engineering and their applications to trauma, maintenance, and regeneration of mesenchymal tissues. The successful candidate will be the inaugural holder of the Tanenbaum Chair in Musculoskeletal Regenerative Medicine at Sinai Health and the University of Toronto. 

The Lunenfeld-Tanenbaum Research Institute is one of Canada's leading biomedical research institutes, located within Mount Sinai Hospital at Sinai Health in downtown Toronto. LTRI's faculty members are internationally renowned for their work in network and systems biology, developmental and cellular biology, endocrinology, structural biology and data science, focusing on improving human health. With numerous discoveries in basic and applied research in cancer, stem cell biology, diabetes, genetic disorders, neurobiology and maternal-infant health, the Lunenfeld-Tanenbaum Research Institute is committed to excellence in health research, the development of early career investigators and the training of young researchers. The Institute provides a research-intensive environment with modern and innovative core facilities that include proteomics, single-cell and spatial genomics platforms, robotics and advanced cellular imaging, which drive technology development and are housed in the Network Biology Collaborative Centre and the Nikon Centre of Excellence. LTRI is also the home of The Centre for Phenogenomics, a state-of-the-art facility for mouse models, and is a founding member of the Nanoscale Biomedical Imaging Facility. LTRI has a fully accredited Biospecimen Repositoryfor biobanking and a dedicated Research Trainee Centre that supports trainees across disciplines from around the world. Close ties with flagship clinical programs focusing on fetal medicine and women's health, cancer and cancer genetics, diabetes, autoimmune/inflammatory diseases, complex medicine, complex orthopedics, geriatrics and infectious disease, and a history of biotech entrepreneurship, ensure the successful application of our research findings.  

Lunenfeld-Tanenbaum Research Institute research groups engage in productive collaborations with the larger University of Toronto community, as well as with national and international groups. The University of Toronto boasts one of the world's most concentrated biomedical research communities, and Sinai Health is part of the Toronto Academic Health Science Network (TAHSN). Toronto is a vibrant, safe, multicultural city with excellent quality of life.

Appointment Details

Investigators at the Lunenfeld-Tanenbaum Research Institute are appointed to independent positions equivalent toAssistant, Associate or Full Professor, depending on experience. Preference for this open position will be given to individuals qualifying at the level of Assistant Professors. The Investigators will be cross-appointed at the University of Toronto in the academic department best aligned with the candidates' backgrounds and research topics.

Candidates must hold a PhD and/or MD degree or equivalent doctoral degree, with postdoctoral experience and an established record of research accomplishment as demonstrated by outstanding publications, presentations at major international conferences, awards and accolades, as well as strong endorsement by reference letters. A track record of securing external funding and interests and experiences in cross-disciplinary collaborations is an asset. The successful candidates will be expected to initiate and lead innovative, independent, and externally-funded research programs of the highest international calibre and impact. 

As an equal opportunity employer who understands that diversity enriches our community and culture, we invite applications from all qualified candidates, including Indigenous Peoples, racialized people, disabled people/people with disabilities, women, and members of 2SLGBTQIA+ communities.  The Lunenfeld-Tanenbaum Research Institute and Sinai Health recognize that scholars have varying career paths and that career interruptions due to personal circumstances can be part of an excellent academic record. Candidates are encouraged to explain any personal circumstances to allow for a fair application assessment. The committee will carefully consider any impact of career interruptions in their decision-making.