Scientist, In Vivo Pharmacology Specialist

3 weeks ago

Vancouver, British Columbia, Canada Zymeworks Full time

About the Role

Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of next-generation biotherapeutics. We are seeking a highly skilled Scientist, In Vivo Pharmacology Specialist to join our team.

Key Responsibilities

  • Design, plan, coordinate, and analyze in vivo immuno-oncology efficacy and PK/PD experiments in collaboration with project team members.
  • Manage studies with internal counterparts and external contract research organizations.
  • Support animal research associates with handling mice, including subcutaneous, intraperitoneal, and intravenous injections, tumor measurements, blood and tissue collection, and health monitoring.
  • Perform mouse study-related administrative tasks, including regulatory documentation and protocol updates.
  • Organize and perform pharmacodynamic evaluation of immune cell function using flow cytometry, histology, and MSD assays.
  • Evaluate emerging technologies, develop new in vivo models, and establish standard protocols and best practices.
  • Provide leadership, mentorship, and scientific/technical guidance to junior staff.
  • Summarize and present results to supervisor in a logical manner, verbally and in written reports or presentations.
  • Analyze data using software, including Excel, GraphPad Prism, FlowJo, and author electronic lab notebook entries suitable for IND enabling documentation.
  • Conduct all activities in accordance with scientific standards, Canadian Council on Animal Care (CCAC), and OH&S regulations and established policies and practices.

Requirements

  • PhD in immunology, pharmacology, cancer biology, or a related scientific discipline with a minimum of 3 years of experience working with rodents or a BSc and minimum 5 years of related experience.
  • Expertise in running xenograft, syngeneic, or humanized mouse tumor models (PBMC and/or CD34) and understanding of immune cell function in treatment and disease.
  • Proficient in animal handling, dosing (SC, IP, IV), and collection of blood and tumor samples, with the ability to consistently perform tail vein injections.
  • Demonstrated understanding of in vivo cancer models, therapeutic mechanisms of actions, relationship of PK to therapeutic activity, and experience with antibody-based therapeutics.
  • Experience with immune cell isolation and flow cytometry.
  • Excellent organizational skills to manage multifaceted studies in a fast-paced environment and meet deadlines within projected budgets.
  • Experience working with contract research organizations for designing, coordinating, and carrying out large-scale in vivo studies and summarizing findings to project teams.

What We Offer

Zymeworks offers a comprehensive total rewards package, including competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. We regularly benchmark our compensation against leading biotechnology companies in our geographies.

The Canadian base salary range for this full-time position is $86,000 - $, with bonus, equity, and benefits. Our salary ranges are determined by role, level, and location. Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate's location and qualifications.

We offer a range of benefits, including industry-leading vacation and paid time off, excellent health and wellness benefits, Zymelife health and wellness benefits, paid time off to volunteer in your community, matching RRSP/K program, employee share purchase program, and employee equity program.

Zymeworks is an equal opportunities employer and welcomes applications from diverse candidates. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, or disability.

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