Principal Scientist
4 weeks ago
AbCellera is seeking a highly motivated Principal Scientist with a strong background in oncology and immunology to join our team. As a key member of our research and development team, you will contribute to the assessment and development of antibody-based oncology drug candidates, driving innovation and advancing our pipeline of programs.
Key Responsibilities- Lead internal preclinical in vivo oncology models to support oncology programs
- Design, support, and interpret pharmacology studies to generate in vivo proof-of-concept and build confidence in selection of molecules for clinical development
- Collaborate with in vitro biology, protein engineering, and pharmacokinetics scientists, as well as external CROs and collaborators, to execute efficient PK/PD studies to identify lead molecules and advance programs to human trials
- Mentor team members in laboratory techniques related to tumour xenograft models
- Report findings to internal program teams and partners to support data-driven decisions
- Evaluate available preclinical and clinical data sets to build testable biological hypotheses for oncology targets and then preclinically assess those hypotheses
- Develop and oversee supporting assays to assess target modulation and downstream effects at the cellular, protein, and gene level
- 10+ years of hands-on experience in oncology, immuno-oncology, and biologics drug development
- PhD in Pharmacology, Immunology, or related field, plus 10+ years of experience in a biopharmaceutical industry setting; MSc and 15 years of relevant experience also considered
- Proven interpersonal skills and ability to create value on cross-functional teams
- Genuine curiosity and interest in discussing innovative ideas in a highly collaborative and fast-paced environment
- Ability to communicate scientific and/or technical concepts with an emphasis on application
- Capacity to independently identify project needs and follow up with constructing and implementing solutions
- Enjoyment of teamwork and building data sets that help predict the success of therapies
AbCellera's hiring range for this role is CAD $141,600 - $177,000 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution. You will also have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, professional development opportunities, and comprehensive health benefits.
About AbCelleraAbCellera is a global company that discovers and develops antibody-based medicines to help people live longer, happier, and more productive lives. We are focused on bringing innovative medicines to patients, both by advancing our internal pipeline of programs and partnering with companies that have novel science or innovative technology.
We look for people with drive and energy, idealists who are passionate about pushing the limits of science and technology to bring better therapies to patients.
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