Senior Manager, Downstream Manufacturing Science and Technology
4 weeks ago
About AbCellera
AbCellera is at the forefront of transforming traditional drug development, dedicated to advancing antibody-based therapies from concept to clinical application. Our diverse team comprises scientists, engineers, creatives, and business professionals united by the belief that scientific progress enhances lives. We have pioneered technologies that unlock high-value drug targets, including antibody-drug conjugates and T-cell engagers for oncology, as well as complex transmembrane proteins for various health conditions.
Position Overview
We are seeking a (Senior) Manager, Downstream Site MSAT to serve as the primary expert in GMP-scale purification of monoclonal and bispecific antibodies. This pivotal role involves collaborating with various departments including manufacturing operations, process development, engineering, quality assurance, and other technical operations. You will be instrumental in driving technology transfer, establishing process controls, developing recipes and batch records, troubleshooting technical issues, and ensuring successful batch production within our state-of-the-art GMP manufacturing facility.
Key Responsibilities
- Provide expert technical leadership in the purification of monoclonal and/or bispecific antibodies.
- Act as the primary liaison during the technology transfer of new processes from development to scale-up, focusing on risk management, recipe formulation, batch record creation, and overall operational success.
- Collaborate with the pilot plant operations team to conduct process risk assessments, raw material evaluations, control strategies, and documentation for technology transfer.
- Contribute to the design of processes and facilities to implement best practices effectively.
- Offer technical support to guide bioprocessing decisions in manufacturing, advocating for optimal process principles alongside quality and production teams.
- Design manufacturing systems that are robust, promote efficient operations, and comply with cGMP standards.
- Identify opportunities for implementing GMP-compliant technologies aimed at enhancing processing efficiency, yield, cost-effectiveness, and operational simplicity.
Qualifications
- A minimum of 8 years of experience in the development and manufacturing of monoclonal and/or bispecific antibodies, along with a bachelor's degree in biotechnology, biochemistry, chemical engineering, molecular biology, or a related field.
- Demonstrated expertise in purification processes, including chromatography, tangential flow filtration, depth filtration, mixing, column packing and maintenance, as well as viral inactivation and filtration techniques.
- In-depth knowledge of downstream processing methods supporting pre-clinical and clinical programs, with a solid understanding of GMP compliance.
- Experience in technology transfer and scaling monoclonal antibody processes from pilot to GMP production.
- A passion for developing dynamic teams and capabilities to achieve significant objectives.
- Creative and innovative mindset with the ability to foresee potential challenges.
- Strong operational insight and risk management skills, with a focus on prioritizing scientific and engineering solutions to minimize process interruptions.
Compensation and Benefits
AbCellera offers a competitive salary range, along with equity options, an annual performance-based bonus, and a 6% RRSP contribution. Additional benefits include a yearly Active Lifestyle Allowance, vacation time, flexible work arrangements, opportunities for professional growth, and comprehensive health benefits. We prioritize scientific and technical mentorship and foster a community-oriented environment that encourages collaboration and connection among our teams.
-
Vancouver, British Columbia, Canada AbCellera Full timeAbout AbCelleraAbCellera is at the forefront of revolutionizing drug development, focusing on antibody-based therapies that enhance patient outcomes. Our diverse team comprises scientists, engineers, creatives, and business professionals committed to advancing scientific knowledge for the betterment of society. We have pioneered technologies to identify...
-
Vancouver, British Columbia, Canada AbCellera Full timeAbout AbCelleraAbCellera is at the forefront of revolutionizing drug development, particularly in the realm of antibody-based therapies. Our diverse team comprises scientists, engineers, creatives, and business professionals, all dedicated to enhancing lives through scientific advancement. We have pioneered technologies that unlock high-value drug targets,...
-
Senior Manager, Downstream Site Operations
1 week ago
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleAbCellera is seeking a highly skilled and experienced Senior Manager, Downstream Site Operations to join our team. As a subject matter expert in purification processes, you will play a key role in process and facility design, driving technology transfer, process controls, recipe and batch record development, technical troubleshooting, and...
-
Senior Manager, Downstream Site Operations
6 days ago
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleAbCellera is seeking a highly skilled and experienced Senior Manager, Downstream Site Operations to join our team. As a subject matter expert in purification processes, you will play a key role in process and facility design, driving technology transfer, process controls, recipe and batch record development, technical troubleshooting, and...
-
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleWe are seeking a highly skilled and experienced Senior Manager, Downstream Site MSAT to join our team at AbCellera. As a subject matter expert in GMP scale purification of monoclonal and bispecific antibodies, you will play a key role in process and facility design, driving technology transfer, process controls, recipe and batch record...
-
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleWe are seeking a highly skilled and experienced Senior Manager, Downstream Site MSAT to join our team at AbCellera. As a subject matter expert in GMP scale purification of monoclonal and bispecific antibodies, you will play a key role in process and facility design, driving technology transfer, process controls, recipe and batch record...
-
Vancouver, British Columbia, Canada AbCellera Full timeAbout AbCelleraAbCellera is pioneering the future of drug development, focusing on antibody-based therapies that enhance patient outcomes. Our diverse team comprises scientists, engineers, and business professionals dedicated to advancing scientific knowledge and improving lives. We have developed cutting-edge technologies aimed at unlocking high-value drug...
-
Vancouver, British Columbia, Canada AbCellera Full timeAbCellera is revolutionizing the landscape of drug development to advance antibody-based therapies from concept to clinical application. Our diverse team comprises scientists, engineers, creatives, and business professionals dedicated to enhancing lives through scientific advancement. We have pioneered technologies that unlock high-value drug targets,...
-
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleWe are seeking a highly motivated and experienced Senior Downstream Process Development Scientist to join our team at AbCellera. As a key member of our process development group, you will be responsible for driving the development and optimization of clinical and commercial manufacturing processes for the purification of antibodies.Key...
-
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleWe are seeking a highly motivated and experienced Senior Downstream Process Development Scientist to join our team at AbCellera. As a key member of our process development group, you will be responsible for driving the development and optimization of clinical and commercial manufacturing processes for the purification of antibodies.Key...
-
GMP Scale Manufacturing Specialist
1 week ago
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleAbCellera is seeking a highly skilled and experienced Senior Manager, Downstream Site Operations to join our team. As a subject matter expert in purification processes, you will play a key role in process and facility design, driving technology transfer, process controls, recipe and batch record development, technical troubleshooting, and...
-
GMP Scale Manufacturing Specialist
6 days ago
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleAbCellera is seeking a highly skilled and experienced Senior Manager, Downstream Site Operations to join our team. As a subject matter expert in purification processes, you will play a key role in process and facility design, driving technology transfer, process controls, recipe and batch record development, technical troubleshooting, and...
-
Senior Manager of Manufacturing Operations
7 days ago
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleWe are seeking a highly motivated and experienced professional to join our team as a Pilot Plant Senior Manager at AbCellera. As a key member of our manufacturing and science team, you will provide technical and strategic leadership in the design, implementation, and operationalization of a 200L scale pilot manufacturing facility.Key...
-
Senior Manager of Manufacturing Operations
1 week ago
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleWe are seeking a highly motivated and experienced professional to join our team as a Pilot Plant Senior Manager at AbCellera. As a key member of our manufacturing and science team, you will provide technical and strategic leadership in the design, implementation, and operationalization of a 200L scale pilot manufacturing facility.Key...
-
Senior Director of Antibody Process Engineering
4 weeks ago
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleAt AbCellera, we are pioneering advancements in drug development, specifically in the realm of antibody-based therapies. Our diverse team, comprising scientists, engineers, and business professionals, is dedicated to enhancing lives through innovative science. We have developed cutting-edge technologies aimed at unlocking high-value drug...
-
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleWe are seeking a highly experienced Senior Director to lead our Process Development team at AbCellera. As a key member of our leadership team, you will be responsible for building and overseeing our CMC functional areas, including Cell Line Development, Upstream & Downstream Process Development, Analytical Development, and Pharmaceutical...
-
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleWe are seeking a highly experienced Senior Director to lead our Process Development team at AbCellera. As a key member of our leadership team, you will be responsible for building and overseeing our CMC functional areas, including Cell Line Development, Upstream & Downstream Process Development, Analytical Development, and Pharmaceutical...
-
Purification Process Expert
1 week ago
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleAbCellera is seeking a highly skilled and experienced Senior Manager, Downstream Site Operations to join our team. As a subject matter expert in purification processes, you will play a key role in process and facility design, driving technology transfer, process controls, recipe and batch record development, technical troubleshooting, and...
-
Purification Process Expert
6 days ago
Vancouver, British Columbia, Canada AbCellera Full timeAbout the RoleAbCellera is seeking a highly skilled and experienced Senior Manager, Downstream Site Operations to join our team. As a subject matter expert in purification processes, you will play a key role in process and facility design, driving technology transfer, process controls, recipe and batch record development, technical troubleshooting, and...
-
Senior Director, Process Development
5 days ago
Vancouver, British Columbia, Canada AbCellera Full timeAbout AbCelleraAbCellera is a biotechnology company that is breaking the barriers of conventional drug development to propel antibody-based medicines from target to clinic. We are a team of scientists, engineers, creatives, and business professionals who believe that advancing science enhances lives. We have developed technologies to unlock high-value drug...
