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Senior Research Director

2 months ago

Hamilton, Ontario, Canada Allergan Full time
Job Summary

We are seeking a highly experienced and accomplished scientist and leader to join our team as a Senior Research Director/Senior Principal Research Scientist at Allergan. This role will lead a team of scientists in designing and deploying in vitro and in vivo pharmacological research to screen and characterize existing and novel toxin therapeutics.

Key Responsibilities:
  • Lead a team of scientists in designing and deploying in vitro cellular and in vivo assays to analyze pharmacological results for screening of novel toxins and full characterization of key molecules.
  • Develop and execute a strategy in alignment with functional goals and key scientific objectives in early stage discovery and during transition to development stage.
  • Partner with protein engineering subject matter experts to design and create novel proteins with desired pharmacological characteristics.
  • Liaise with toxicology, immunology, bioanalytical, clinical development, and commercial colleagues to advance programs from research to development.
  • Manage project activities and professional development of a team of scientists through effective mentoring, guidance, and supervision.
  • Advance scientific expertise within the function and collaborate with cross-disciplinary teams to advance programs from research to development.
  • Develop forward-looking strategies to identify and implement novel assays, measurements, and technologies that increase throughput, quality, and reproducibility of pharmacological results.
  • Ensure the quality and effectiveness of key project results through sound design, early risk assessments, and implementation of fallback strategies.
  • Provide expert advice and share knowledge with direct reports, peers, and senior management.
  • Provide guidance to develop both the skills and the careers of direct reports.
  • Train and mentor functional colleagues and assess current and emerging business challenges to achieve functional goals.
  • Identify and integrate emerging scientific trends from internal and external sources into short-term functional objectives.
  • Responsible for data management, data QC, and technical report writing.
  • Author regulatory documents in compliance with Federal Regulations, including protocols, study reports, relevant sections of investigator brochures and INDs, white papers, and other similar documents.
  • Present program updates and research strategies to functional and non-functional leaders as well as potential and existing partners.
  • Maintain awareness of emerging literature and science in the neurotoxin field and author scientific disclosures as needed.
Qualifications:
  • Extensive experience with pharmacological assays, focusing on in vitro cellular and in vivo pharmacology in an industrial research environment, with at least 10+ years of experience managing teams and cross-functional projects.
  • Understanding of protein engineering and ability to partner with SMEs to design and create new proteins with desired pharmacological characteristics.
  • Direct experience with peripheral neuronal animal models.
  • Proven track record of driving early to late-stage discovery programs.
  • Extensive knowledge and experience in both central and peripheral neuroscience.
  • At a minimum, conversant in enzyme kinetics, toxicologic and histologic assays and methods.
  • Extremely organized and experienced with documentation of experimental plans, budget, timelines, and technical reports.
  • Experience in authoring and QCing technical reports and regulatory documents.
  • Highly organized and self-directed, capable of leading multiple complex research programs in parallel.
  • Solid understanding of standard statistical analysis of scientific data using data software tools (e.g., Prism, SigmaPlot, and SPSS).
  • Detail-oriented and precise in written and oral communication.
  • Effective problem-solving skills.
  • Ability to critically analyze data and lead teams to solve issues and make the best strategic decisions.
  • Highly collaborative, team-oriented, and considerate of the needs of others.
  • Strong interpersonal skills and ability to collaborate with diverse groups within the organization and external partners.
  • Knowledge of pharmaceutical development processes, including lead characterization, CMC considerations, and GxP tox & safety.
  • Experience evaluating internal and external research and development programs.
  • Proven team leadership and management abilities, including experience mentoring, guiding, supervising, and developing scientific personnel with various backgrounds and training levels.
  • Ability to create an inclusive environment where diverse ideas, viewpoints, and backgrounds are valued; willingness and ability to lead inclusively and demonstrate a commitment to listen and consider all points of view.
Education & Experience:

PhD in Biology, Pharmacology, Neuroscience, Biochemistry, or equivalent field with 10+ years of related work experience in biotech or pharma; Master's Degree Science or PharmD with 16 years of related work.