Research Associate
1 week ago
Reporting to the laboratory director Dr. Manousaki, the bioinformatician/data manager will identify and analyze genetic variants from genotyping and sequencing data (exome and whole genome). Using this data, he/she will further develop and implement polygenic risk scores. The research projects explore the impact of genetic variants on complex traits affecting growth and cardiometabolic health in childhood. For more information, please refer to the laboratory website: chusj-geneticepi.org
- Identification of genomic variants by conducting genome-wide association studies -GWAS. The data to be analyzed include genotyping data and sequencing data (exome and whole genome) from large biobanks, such as the UK Biobank.
- Calculate polygenic risk scores and test them in linear and logistic regression analyses.
- Conduct Mendelian randomization studies.
- Manage and coordinate the laboratory’s bioinformatics work.
- Develop and write data processing procedures in the laboratory.
- Organize and prioritize data on servers (Compute Canada).
- Document and communicate the analysis process, results, tools and techniques used;
- Interact with laboratory members to develop analysis strategies.
**Requirements and skills**
- Level of education: Master’s or PhD in bioinformatics or equivalent;
- Experience in coding on one of the following languages: Linux, python, R, etc.;
- Knowledge of epidemiology;
- Ability to work in a group on several projects;
- Good skills in “Data management”;
- Knowledge of machine learning is an asset;
- Professional experience of more than 2 years is an asset;
- Experience in genetics and genomics.
**Employment conditions**
Union of employees of the CHU Sainte-Justine Research Center (SECR)
Salary scale: Level 4 - between $32.11/hr and $47.70/hr (depending on employment experience)
Researcher in charge: Dr. Despoina Manousaki
Position: Regular full-time (35 hours per week)
Expected start date: Immediate
**Description du poste**
Sous la responsabilité du directeur du laboratoire Dre Manousaki, le bioinformaticien (ne)/data-manager devra identifier et analyser des variants génétiques à partir des données de génotypage et de séquençage (exome et génome complet). Utilisant ces données, il/elle devra davantage développer et implémenter des scores de risque polygéniques. Les projets de recherche explorent l’impact des variants génétiques sur des traits complexes touchant la croissance et la santé cardiometabolique dans l’enfance. Pour plus d’information, merci de vous référer au site web du laboratoire : chusj-geneticepi.org
- Identification des variants génomiques en menant des études d’association pangenomique -GWAS. Les data à analyser comprennent des données de génotypage et des données de séquençage (exome et génome complet) provenant des larges biobanques, telle que la UK Biobank.
- Calculer des scores de risque polygénique et les tester dans des analyses de régression linéaire et logistique.
- Mener des études de randomisation Mendélienne.
- Gestion et coordination du travail en bio-informatique du laboratoire.
- Développer et rédiger des procédures de traitement des données dans le laboratoire.
- Organiser et hiérarchiser les données sur les serveurs (Compute Canada).
- Documenter et communiquer le processus d’analyse, résultats, outils et techniques utilisés;
- Interagir avec les membres du laboratoire afin d’élaborer des stratégies d’analyses.
**Exigences et aptitudes**
- Niveau d’études : Maitrise ou PhD en bioinformatique ou équivalent;
- Expérience en code sur un des langages suivant : Linux, python, R, etc. ;
- Connaissance en épidémiologie;
- Capacité de travailler en groupe sur plusieurs projets;
- Bonne compétence en « Data management »;
- Connaissance en apprentissage automatique (machine learning) est un atout;
- Une expérience professionnelle de plus de 2 ans est un atout;
- Une expérience en génétique et génomique.
**Conditions d’emploi**
Syndicat des employés du Centre de recherche du CHU Sainte-Justine (SECR)
**Échelle salariale**:Niveau 4 - entre 32.11 $/hr et 47.70$/hr (selon expérience d’emploi)
**Chercheur** **responsable**: Dr Despoina Manousaki
**Poste** : Régulier à temps complet (35 heures par semaine)
**Date prévue d’entrée en fonction **:Immédiate
Pay: $58,000.00-$86,000.00 per year
**Benefits**:
- Casual dress
- Company events
- Dental care
- Extended health care
- Flexible schedule
- Life insurance
- On-site childcare
- On-site parking
- Paid time off
- RRSP match
Schedule:
- Monday to Friday
Work Location: Hybrid remote in Montréal, QC H3S 1W3
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