Post Doctorate Fellow
5 months ago
Pathology and Molecular Medicine
Analytical chemistry post-doctoral student research position
**Development of clinical chemistry LC-MS-MS assays**
Applications are invited for a 1-year post-doctoral fellowship position to develop clinical LC-MS-MS assays with the Hamilton Regional Laboratory Medicine Program (HRLMP) HRLMP clinical mass spectrometry laboratories to develop one or more assays in the areas of**:newborn screening, biochemical genetics, toxicology, special chemistry**.
The HRLMP operates clinical laboratories for the hospitals in the Hamilton, Ontario region, in addition to offering reference laboratory services for Canada. In partnership with the Department of Pathology and Molecular Medicine, McMaster University, The PDF will work within the Specific assays will be developed according to lab priorities and instrument and technical staff availability. Most PDFs would complete more than one assay development project during the year, depending on the complexity of the assay.
**Co-supervisors**:
**Objective**:
Development and clinical validation of ultra-performance liquid chromatography tandem mass spectrometry (LC-MS-MS) methods for clinical use
**Background**:
This is an excellent post-doctoral position for those seeking a career in clinical biochemistry.
Each assay will follow a similar project outline:
- Create a project plan based on literature review and clinical goals and order any needed chemicals.
- Develop and optimize the analytical method for LC-MS-MS.
- Clinically validate the method according to Clinical Laboratory Standards Institute (CLSI) protocols.
- Pilot test the method in a clinical setting.
- Disseminate the research (conference presentations, publications)
**Skills and Qualifications**:
- PhD or MD/PhD is required (completed prior to start date)
- Graduate degree should be in a field related to biochemical genetics, toxicology, or analytical chemistry
- Experience in some or all of the following techniques is required: mass spectrometry, spectrophotometry, liquid and gas chromatography, sample preparation (blood, urine) for biochemical analysis
- Experience in study design related to analytical method optimization and validation is preferred
- Self-motivated, detail-oriented, and results-driven
- Strong ability to take initiative and work independently, as well as in a team environment
- Excellent written and oral communication skills
- Proven track record of publications in high quality journals required; some successful minor grant funding desirable
**Duration and Funding**:
**How to apply**:
**About the HRLMP**
Hamilton is the seventh largest city in Canada, with a diversified economy, a multicultural population, an active arts and culture scene, breathtaking natural beauty, and safe and welcoming neighborhoods. We believe HRLMP is a great place to work - and Hamilton is a great place to call home. The HRLMP serves Hamilton and the surrounding region, home to over two million people. Our program spans four acute care hospital sites and one community hospital and is part of two hospital corporations (Hamilton Health Sciences and St. Joseph’s Healthcare Hamilton). One of our hospital sites, the Juravinski Hospital and Cancer Centre (JHCC) is a regional referral centre for central-west Ontario. HRLMP’s pathologists care for patients across this region and collaborate with healthcare professionals in Hamilton and in surrounding communities.
**Why McMaster?**
McMaster University is home to some of the best minds and laboratories in the country. McMaster has a well-deserved reputation as a hotbed of discovery and innovation and is consistently ranked among Canada's top research-intensive universities. The Faculty of Health Sciences is unique as the only Canadian University that combines, in one Faculty, schools of medicine, nursing, rehabilitation sciences, midwifery programs, Bachelor of Health Sciences, physician assistant and postgraduate health sciences education. This is a specific initiative to train medical team members in a collaborative, interdisciplinary approach to developing effective and efficient health care.
The Department of Pathology and Molecular Medicine represents a unique integration of basic biomedical science and clinical medicine affiliated with the Hamilton Regional Laboratory Medicine Program (HRLMP). Several of our Faculty hold prestigious research chairs and funding awards. It is an exciting and eventful period in medical research and education, and many in the Department are contributing to significant breakthroughs in their specific areas. Many of our Faculty are educators in the Bachelor of Health Sciences and Undergraduate Medicine program and our Postgraduate Training Programs in Laboratory Medicine, considered among the best in Canada. The successful applicant will join over 140 full-time/part-time faculty.
McMaster University is located on the traditional territories of the Haudenosaunee and Mississauga Nations and within
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