Research Scientist 2, Cmc, Analytical Chemistry

6 months ago

Vancouver, Canada Xenon Pharmaceuticals Inc. Full time

**Who We Are**:
**At Xenon Pharmaceuticals (NASDAQ**: XENE), we are committed to providing a brighter future for patients suffering from neurological disorders. Our employees are smart, passionate, dedicated, and driven by their incredibly important work to discover, develop, and deliver innovative medicines for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

**What We Do**:
We are advancing an exciting portfolio of neurology therapies in our product pipeline, with a focus on commercializing novel treatments for epilepsy. Building upon the positive results and compelling data from our XEN1101 Phase 2b “X-TOLE” study in adult patients with focal epilepsy, our XEN1101 epilepsy program includes multiple Phase 3 clinical trials in patients with focal onset seizures and primary generalized tonic clonic seizures. In addition, based on topline data from our XEN1101 Phase 2 “X-NOVA” clinical trial in adults with major depressive disorder (MDD), we are actively exploring the future development of XEN1101 in MDD and potentially other indications. Our pipeline also includes other early-stage research programs, and we are proud of the leading-edge science coming out of our discovery labs. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

**About the Role**:
**RESPONSIBILITIES**:

- Develop various analytical methods for analyzing the purity and impurities of starting material, intermediates, drug substances, and drug products from Xenon’s internal pipeline.
- Assess current analytical methods and optimize where applicable.
- Work with CMC QC to transfer methods to our outsourced contract organizations.
- Support QC with method qualification/validation studies by designing and/or reviewing validation protocols, reports and raw data as needed.
- General laboratory maintenance and monitoring.
- Write standard operating procedures and/or standard testing procedures as required. Develop in-house technical documents for the qualification, use and maintenance of analytical equipment in the CMC group.
- Organize and file internal data, protocols, and reports.
- Effective time management with an emphasis on prioritizing projects as needed.
- Keep up to date and detailed records of experiments and data analysis within an Electronic Lab Notebook system. Ensure experiments are counter-signed on a monthly basis.
- Ensure the laboratory environment is safe and well-organized; follow and keep up to date with Health & Safety policies.
- Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.
- Other duties as assigned.

**QUALIFICATIONS**:

- An MSc or PhD in analytical/physical/organic chemistry, or pharmaceutical sciences is strongly preferred.
- A minimum of 3 years’ experience in the pharmaceutical industry, directly related to analytical development on small molecule drug substances and drug products is required.
- Good chromatography, spectroscopy knowledge with expertise in impurity identification using LCMS and GCMS mass spectra is highly preferred. Relevant experience in the field of preformulation, solid state chemistry would be a plus.
- Excellent written and oral communication skills, including the ability to communicate with scientific and non-scientific personnel.
- Excellent attention to detail and commitment to providing reliable, accurate, high quality data.
- Self-motivated with good organizational skills and the ability to manage multiple competing priorities.
- Strong interpersonal and team skills to work both independently and collaboratively as part of a multidisciplinary team.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.
Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

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