Msat Scientist I

3 weeks ago

Toronto, Canada Centre for Commercialization of Regenerative Medicine Full time

**About CCRM**:
**Department**: Deliver

Position Summary
This is a critical role that oversees all the cell and gene therapy Good Manufacturing Practices (GMP) operations and technology transfer activities. As the Manufacturing Sciences and Technology (MSAT) Scientist I at CCRM, you are a seasoned individual in the field of cell and gene therapy manufacturing processes, with experience following GMP and driven by the opportunity to enable the clinical translation of cell therapy and regenerative medicine. This challenging position is available in the process transfer and support function of MSAT at our Centre for Cell and Vector Production (CCVP) facility. In this position you are the primary technical support person for manufacturing processes and must thoroughly understand the manufacturing process, aseptic handlings, process mapping, risk analysis, process implementation and other technology transfer related issues. The MSAT Scientist I is expected to actively participate in the planning and problem-solving of technology transfer related issues and the execution of all technology transfer studies in support of GMP activities at the GMP facility. The MSAT Scientist I will work in cooperation with other departments during the technology transfer and the individual will be involved in training other MSAT associates.

**Responsibilities**:

- Execution of MSAT laboratory studies in the lab to support GMP activities for downstream viral vector manufacturing at small and large scale.
- Drive the process transfer and provide process support as per agreed timelines in close collaboration with internal and external parties.
- Responsible for the introduction and support of qualification of new process technologies into GMP manufacturing, while managing technical risks associated with process transfer.
- Review client manufacturing processes or standard operating procedures (SOPs), bill of equipment (BOE) and bill of materials (BOM) for GMP manufacturing compliance.
- Identify risks and develop mitigation plans in the downstream process and enable quick and robust decision-making through efficient team collaboration.
- Responsible for analyzing and managing the risks associated with process transfer, and the introduction of new raw materials for both pilot and production scale batches, and transfer complex processes from international development and pilot scale facilities.
- Perform all functions associated with process transfer and process support, e.g., develop process understanding; perform gap analysis/failure mode and effects analysis (FMEA); generate process models; author/review process descriptions and batch records, change controls, perform process monitoring (manufacturing data summary and analysis, data presentation).
- Provide guidance on process transfer and support activities to members of the team.
- Prepare or review user requirement specifications (URS) of all new equipment and work closely with the Commissioning, Qualification and Validation (CQV) and facility teams to perform risk assessment or impact assessment.
- Ensure major steps of process transfer, including feasibility runs, engineering runs and APS runs and that they are performed successfully.
- Participate in troubleshooting and serve as investigation lead for process impacting deviations and investigations.
- Provide technical guidance on change controls and how they might impact customer processes.
- Assess all major deviations, including those that impact product quality:

- Identifies potential root causes using a systematic approach;
- Able to identify potential solutions;
- Performs or can understand all types of complex data analysis such as multiple linear regression analysis, ANOVA, multivariate analysis;
- Provide support for the manufacturing floor regarding pre-campaign training, support during critical manufacturing operations, troubleshooting, etc.
- Provide expertise in presentations, white papers, or other formats to communicate the organization’s expertise to our industry colleagues and partners
- Be aware of external biopharmaceutical manufacturing technology advancements, understand and introduce new technologies and how they may be applied to process innovation, cost, or yield improvement.
- Keep current with advances in the cell and gene therapy field.
- Collaborate with process development teams on improving performance.
- Provide training and guidance to other MSAT associates and must be able to independently perform deliverables assigned to the individual.
- Lead projects related to induced pluripotent reprogramming, immune-oncology, viral vector production etc.

**Requirements**:

- BSc with 6+ years of experience in biological sciences, biomedical/chemical engineering/GMP, or another relevant field; MSc with 5+ years of experience or PhD with 4+ years of experience in biological sciences, biomedical/chemical engineering/GMP, or another relevant field is preferred.
- Solid knowledge and experience in viral

  • Data Scientist I

    1 month ago

    Toronto, Canada TD Bank Full time

    **Data Scientist I**: - 416264BR **Job Category - Primary** - Enterprise Data & Analytics **Work Location** - TD Centre - South - 79 Wellington Street West **Employment Type** - Regular **City** - Toronto **Time Type** - Full Time **Province/State** - Ontario **Hours** - 37.5 **Workplace Model** - Hybrid **Pay Details** **Department...

  • Food Scientist I

    1 week ago

    Toronto, Canada Stefanini Full time

    **Stefanini is looking for a Food Scientist I in Gladstone, Toronto CAD** For quick apply, please reach out to **Cathryn Villanueva** **Responsibilities**: - Conduct research and development activities to create new food products or improve existing ones - Collaborate with cross-functional teams to develop and implement new product concepts - Conduct...

  • Data Scientist I

    1 month ago

    Toronto, Canada TD Bank Full time

    416264BR Enterprise Data & Analytics Toronto, ON August 9, 2023 Hours 37.5 Workplace Model Hybrid Pay Details Department Overview What does TD stand for? For starters, we believe in visionary leadership and insights. We believe in using every resource at our disposal to better serve our clients, and for almost every department, that begins with...

  • 4865 Associate Scientist I

    4 weeks ago

    Toronto, Canada Luminex Full time

    Please note this posting is for a limited term assignment. ASSOCIATE SCIENTIST I - AGS - CA JobDescription JOB INFORMATION **Job Title**: ASSOCIATE SCIENTIST I - AGS - CA JOB SUMMARY Participate in the Company's day-to-day Research and Development activities which include: design, execution and interpretation of scientific experiments and design and...

  • Food Scientist

    1 week ago

    Toronto, Canada Stefanini Full time

    **Stefanini is looking for a Food Scientist I in Gladstone, Toronto CAD** **Responsibilities**: - Conduct research and development activities to create new food products or improve existing ones - Collaborate with cross-functional teams to develop and implement new product concepts - Conduct trials in bakeries to test and optimize product formulations -...

  • Data Scientist

    4 weeks ago

    Toronto, Canada Ministry of Children, Community and Social Services Full time

    Do you love to straddle the worlds of business, math, and technology? When faced with a new problem, is your first instinct “How can I use data to solve this problem?” Are you ready to work with your fellow data science practitioners to support policies and programs that benefit millions of Ontarians? If you answered yes, then we have an opportunity...

  • Senior Scientist

    2 weeks ago

    Toronto, Canada Ombudsman Ontario Full time

    Join the Ontario Science Centre (OSC) - one of Canada's most visited cultural attractions and a world-renowned educational institution that attracts a million visitors a year. The OSC is currently looking for a Senior Scientist to join the Science team.OPS Commitment to Diversity, Inclusion, Accessibility, and Anti-Racism:We are committed to build a...

  • Senior Scientist

    2 weeks ago

    Toronto, Ontario, Canada Ombudsman Ontario Full time

    Join the Ontario Science Centre (OSC) - one of Canada's most visited cultural attractions and a world-renowned educational institution that attracts a million visitors a year. The OSC is currently looking for a Senior Scientist to join the Science team.OPS Commitment to Diversity, Inclusion, Accessibility, and Anti-Racism:We are committed to build a...

  • Senior Machine Learning Scientist

    4 weeks ago

    Old Toronto, Canada Extreme Networks, Inc. Full time

    Extreme Networks Named to Computerworld’s 2023 List of Best Places to Work in IT!Over 50,000 customers globally trust our end-to-end, cloud-driven networking solutions and rely on our top-rated services and support to accelerate their digital transformation efforts and deliver progress like never before and with double digit growth year over year, no...

  • Senior Machine Learning Scientist

    1 month ago

    Old Toronto, Canada Extreme Networks, Inc. Full time

    Extreme Networks Named to Computerworld’s 2023 List of Best Places to Work in IT!Over 50,000 customers globally trust our end-to-end, cloud-driven networking solutions and rely on our top-rated services and support to accelerate their digital transformation efforts and deliver progress like never before and with double digit growth year over year, no...

  • Senior Machine Learning Scientist

    4 weeks ago

    Old Toronto, Canada Extreme Networks, Inc. Full time

    Extreme Networks Named to Computerworld’s 2023 List of Best Places to Work in IT!Over 50,000 customers globally trust our end-to-end, cloud-driven networking solutions and rely on our top-rated services and support to accelerate their digital transformation efforts and deliver progress like never before and with double digit growth year over year, no...

  • Senior Geospatial Data Scientist

    1 day ago

    Old Toronto, Canada Peak Power Full time

    At Peak Power, we’re making dirty power plants obsolete.The current, centralized electricity system is not sustainable. Between the climate crisis, state-wide blackouts, aging infrastructure, and rising costs, the system needs a huge overhaul. The demand for electricity is high – and getting higher – and big power plants aren't meeting our needs. We...

  • Senior Geospatial Data Scientist

    1 day ago

    Old Toronto, Canada Peak Power Full time

    At Peak Power, we’re making dirty power plants obsolete.The current, centralized electricity system is not sustainable. Between the climate crisis, state-wide blackouts, aging infrastructure, and rising costs, the system needs a huge overhaul. The demand for electricity is high – and getting higher – and big power plants aren't meeting our needs. We...

  • Senior Geospatial Data Scientist

    3 days ago

    Old Toronto, Canada Peak Power Full time

    At Peak Power, we’re making dirty power plants obsolete.The current, centralized electricity system is not sustainable. Between the climate crisis, state-wide blackouts, aging infrastructure, and rising costs, the system needs a huge overhaul. The demand for electricity is high – and getting higher – and big power plants aren't meeting our needs. We...

  • Research Technician I

    4 weeks ago

    Toronto, Canada University Health Network Full time

    **Job #913395** **Position: Research Technician I** **Site: Toronto General Hospital Research Institute** **Department: Experimental Therapeutics - Infection and Immunity** **Reports To: Senior Scientist** **Salary: $25.10-$31.38 Commensurate with experience and consistent with UHN Compensation Policy** **Hours: 37.5 hours/week** **Status: Full-time,...

  • Environmental Scientist

    4 weeks ago

    Toronto, ON, Canada Ausenco Full time

    Ausenco is a fast-growing company with big ideas. We redefine what’s possible in some of the world’s most complex projects and toughest environments. Delivering innovative, value-add consulting, project delivery, asset operations and maintenance solutions is what we do. From 26 offices in 15 countries, with projects in over 80 locations worldwide, we...

  • Environmental Scientist – Ontario

    4 weeks ago

    Old Toronto, Canada Ausenco Full time

    Ausenco is a fast-growing company with big ideas. We redefine what’s possible in some of the world’s most complex projects and toughest environments. Delivering innovative, value-add consulting, project delivery, asset operations and maintenance solutions is what we do. From 26 offices in 15 countries, with projects in over 80 locations worldwide, we...

  • Environmental Scientist – Ontario

    4 weeks ago

    Old Toronto, Canada Ausenco Full time

    Ausenco is a fast-growing company with big ideas. We redefine what’s possible in some of the world’s most complex projects and toughest environments. Delivering innovative, value-add consulting, project delivery, asset operations and maintenance solutions is what we do. From 26 offices in 15 countries, with projects in over 80 locations worldwide, we...

  • Environmental Scientist – Ontario

    1 month ago

    Old Toronto, Canada Ausenco Full time

    Ausenco is a fast-growing company with big ideas. We redefine what’s possible in some of the world’s most complex projects and toughest environments. Delivering innovative, value-add consulting, project delivery, asset operations and maintenance solutions is what we do. From 26 offices in 15 countries, with projects in over 80 locations worldwide, we...

  • Data Scientist, Ai Model Risk

    1 week ago

    Toronto, Canada Royal Bank of Canada Full time

    **Come Work with Us!** At RBC, our culture is deeply supportive and rich in opportunity and reward. You will help our clients thrive and our communities prosper, empowered by a spirit of shared purpose. Whether you’re helping clients find new opportunities, developing new technology, or providing expert advice to internal partners, you will be doing work...