Research Fellow

2 weeks ago

Toronto, Canada SickKids Full time

**About SickKids**:
Dedicated exclusively to children and their families, The Hospital for Sick Children (SickKids) is one of the largest and most respected paediatric healthcare centres in the world. As innovators in child health, we lead and partner to improve the health of children through the integration of healthcare, leading-edge research and education. Our reputation would not have been built - nor could it be maintained - without the skills, knowledge and experience of the extraordinary people who come to work here every day. SickKids is committed to ongoing learning and development, and features a caring and supportive work environment that combines exceptionally high standards of practice.

When you join SickKids, you become part of our community. We share a commitment and determination to fulfill our vision of _Healthier Children. A Better World_.

Don’t miss out on the opportunity to work alongside the world’s best in paediatric healthcare.

**Position Description**:
**Research Fellow available**

We are looking for a highly motivated, independent, collaborative postdoctoral researcher who has a strong interest in studying the molecular mechanism underlying amyotrophic lateral sclerosis (ALS).

The Jeehye Park laboratory in the Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Canada, seeks to understand the molecular mechanisms underlying ALS. We recently created a new ALS mouse model, MATR3 S85C knock-in mouse, which recapitulates early-stage features of human ALS including motor deficits, Purkinje cell degeneration, motor neuron defects and neuroinflammation (please see: Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS - PubMed (nih.gov)). With this clinically relevant model, we employ genetics, molecular and cell biology, RNA profiling and high-throughput genetic screens to (1) identify the early disease events in the neurodegenerative process and (2) elucidate the mechanism underlying selective neuronal vulnerability. Our goal is to advance our understanding of the disease mechanism and enable development of early intervention strategies for ALS.

The Hospital for Sick Children is renowned as one of the most respected pediatric health science centers in the world. The research institute of the Hospital for Sick Children, named as the Peter Gilgan Centre for Research and Learning (PGCRL) About SickKids Research Institute | SickKids, is a 21-story building comprised of many different labs in various research fields from cell biology to genetics to neuroscience to metabolism. This institute also offer various core facilities for RNA sequencing, proteomics, flow cytometry, imaging, animals and more. Having many labs with different research expertise and core facilities under one roof interconnects various disciplines and enhances research collaboration. This institute provides an outstanding training environment for the next generation of scientists and leaders.

**Requirements**:

- Applicants must have a PhD in biology or related fields. The applicants with the background of cell and molecular biology, genetics or neuroscience are preferred, but not required. Degree must be obtained within the last 2 years.
- Applicants who have prior experience with mouse models are preferred, but not required.
- Applicants who are curious and open-minded to learn new research field, techniques and skills.
- Applicants who are highly motivated, organized, creative, independent but also able to work collaboratively with other team members.
- Applicants who can supervise graduate and undergraduate students.
- Fluency in English and great interpersonal and communication skills.
- Proven track record of publications (a minimum of one first author publication with two co-author papers)

**How to Apply**:
1. Cover letter that includes a description of previous research experience and research interests

2. Curriculum Vitae

**Our Commitment to Diversity**:
The children and families we care for are from a variety of communities, and so are our employees. We welcome and encourage everyone to join our organization and be part of our team.

Thank you for your interest in joining SickKids. Only those applicants selected for an interview will be contacted. In accordance with our Hospital policy, employment at SickKids is conditional upon the Hospital’s receipt of all necessary documentation.

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