Scientist, Mass Spectrometry

2 weeks ago

Vancouver, Canada AbCellera Biologics Full time

AbCellera is an energetic, and rapidly growing tech company with an amazing team that searches, decodes, and analyzes natural immune systems to find antibodies that its partners can develop into drugs to prevent and treat disease. Working at the interface of computation, engineering, and biology, AbCellera is rebuilding the front-end process of how drugs are discovered with a discovery platform that integrates modern technologies from engineering, microfluidics, single-cell analysis, high-throughput genomics, machine learning, and hyper-scale data science. With over 400 AbCellerites and growing, we’re expanding our capabilities to include CMC development and GMP manufacturing of antibodies to bring therapies from idea to patients, faster.

We are seeking a highly motivated Scientist to join CMC Analytical Development at AbCellera. In this capacity, the Scientist will assist in a number of high priority activities including the build out of mass spectrometric capabilities, the design and development of mass spectrometric workflows, and the design of a technical strategy to support mass spectrometric demand within the Process Development department. The role will involve hands-on instrument setup and optimization in addition to the development of workflows designed to support all activities within the Process Development organization (sequence verification, chemical modification quantitation, sequence variant analysis, intact mass analysis, etc).

This is a very exciting opportunity to join one of Canada’s most innovative biotech companies. We are breaking ground on new capabilities in Canada and this role will require the successful individual to roll up their sleeves and dive into building advanced analytical capabilities in our rapidly emerging CMC organization. This is trail blazing work and will resonate with individuals who are inspired by ground-up builds, establishing new capabilities, and comfortable navigating through ambiguity.

**We'd love to hear from you if**
- You are an innovator and ready to help new approaches to the discovery and development of therapeutics
- You have a strong desire to support early antibody discovery work by developing ways to improve and speed up the discovery to CMC development to GMP manufacturing paradigm
- You are ready to revolutionize therapeutic development and move at lightning speed to create a legacy in our industry
- You are an outstanding communicator and teammate
- You are highly motivated and excited about the opportunity to work with an inspired team on challenging problems that matter

**How you might spend your days**
- Setting up, optimizing, and maintaining mass spectrometry instrumentation.
- Designing, developing and, when necessary, qualifying LC-MS-based analytical methods in support of bioprocess development activities (cell line development, upstream/downstream process development, formulation and drug product development).
- Performing detailed protein characterization including amino acid sequence confirmation, identification and quantitation of post-translational modifications, disulfide bond mapping and integrity analysis, sequence variant analysis, intact/reduced mass analysis, etc.
- Communicating within and across organizations to align methodology and share analytical findings.
- Publishing and communicating technical reports reflecting MS-based investigations and findings.
- Leading method transfers to or co-qualifications with other testing labs, investigations, test performance monitoring/trending, and be responsible for the quality and scientific integrity of data generated in their assigned area.
- Contributing MS expertise to CMC projects, ensuring responsibilities are completed on-time and in alignment with GxP expectations (21 CFR part 11 compliance, documentation, etc).
- Exploring and evaluating new technologies to improve throughput, precision, accuracy, capabilities, and overall quality of methods employed.

**Required skills and experience**
- A PhD degree with 2+ years experience or MS degree with 4+ years relevant experience or equivalent or BS with 6+ years relevant experience or equivalent and a degree in biology, biochemistry, or chemical biology.
- Familiarity with regulatory guidelines and practices (FDA, EMA, ICH, etc)
- Experience with Analytical Quality-by-Design (AQbD) methodology.
- Experience with analytical method development, qualification, and technology transfer activities.
- Experience or familiarity with analytical platforms such as Empower, Xcalibur, MassLynx, Proteome Discoverer, Byos, etc.
- Experience and proficiency with ELNs (IDBS, Benchling, etc)
- Expert knowledge of LC-MS based protein analytics to address life sciences or drug discovery questions, protein characterizations, and targeted protein quantitation.
- Experience with lab automation for MS analyses including antibody-based enrichment methods.
- Expertise in operating, maintaining and troubleshooting LC-MS equipment as well as other ins

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