Scientist I, Bioinformatics

2 months ago

Burnaby, Canada Iovance Biotherapeutics Full time

Overview

Scientist I, Bioinformatics, leads the TCR sequencing analysis platform at Iovance. The successful candidate may also be responsible for developing and implementing other data analysis pipelines for Next Generation Sequencing and other genomics applications as applied to autologous cell therapy.

Essential Functions and Responsibilities

  • Lead Bioinformatics analyses of TCR sequencing data related to the study of preclinical and clinical TIL products.
  • Perform biological and immunological interpretation of sequencing data; summarize and present results with clear conclusions.
  • Guide scientists on the design of next-generation sequencing experiments.
  • Develop and implement data analysis pipelines for Next Generation Sequencing and other genomics applications, from raw instrument output to interpretable and publishable results. These include but are not limited to sequence alignment, variant calling differential expression analysis, and single-cell clustering.
  • Contribute to publications at international conferences and in peer-reviewed journals.
  • Maintain expertise in state-of-the-art NGS applications and Bioinformatics methods.

Required Education, Skills, and Knowledge

  • PhD degree in Bioinformatics, Biology, Immunology, Bioengineering, or relevant fields with 1+ years of experience.
  • Fluent in Shell, R, and Python programming. Experience working on a Linux server either locally or on the cloud.
  • Extensive hands-on experience in analyzing next-generation sequencing data on applications including but not limited to single-cell DNA and RNA sequencing, whole transcriptome and whole exome sequencing, targeted DNA and RNA sequencing, etc.
  • Excellent problem-solving and collaboration skills.

Preferred Education, Skills, and Knowledge

  • Deep knowledge of Immunology, especially T-cell biology.
  • Industry experience preferred.
  • Experience in assay validation, software verification and validation a plus.

Work Environment

This position will work in both an office and a laboratory setting. When in the lab, there may be a risk of exposure to hazardous or biological waste within the environment through receipt, transport, storage, preparation, dispensing, administration, cleaning, and/or disposal of contaminated areas and waste.

The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Management retains the discretion to add or to change the duties of the position at any time.

Iovance is committed to cultivating and offering a diverse and inclusive work environment. As an equal-opportunity employer, our employees and applicants will be considered without regard to an individual’s race, color, religion, sex, pregnancy, national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information, military and veteran status, and any other characteristic protected by applicable law. If you need assistance or accommodation to apply to one of our opportunities, please contact careers@iovance.com.

By voluntarily providing information and clicking “Submit Application”, you explicitly consent to the collection and use of your personal information for the purposes described above and in our Candidate Privacy Notice.

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