Principal Investigator, Translational Science
4 weeks ago
About us:Ventus Therapeutics is a clinical-stage biopharmaceutical company deploying leading-edge structural biology and computational chemistry tools to create novel small molecule medicines for challenging targets in immunology, inflammation, and neurology.Our proprietary drug discovery platform, ReSOLVE, gives us the ability to discover and develop medicines through unique insights into protein targets and to create dynamic blueprints that can guide the development of differentiated therapies at a fast pace. We aim to use the ReSOLVE platform to improve the way medicines are discovered and developed, with the ultimate goal of restoring the health of people facing serious illnesses.Position overview:Ventus is seeking an experienced translational scientist to lead the design and execution of biomarker strategies in support of our early and late-stage research programs. The candidate will be responsible for the development of translational biomarker approaches that measure target engagement, pharmacodynamics and disease pathology. As a strategic leader within a multidisciplinary team, the candidate will ensure that biomarker strategies align with the most current understanding of inflammatory disease biology and enable early clinical proof-of-concept. The candidate is expected to take a hands-on approach in the pre-clinical validation of such approaches using disease biospecimens. This role is a unique opportunity to work at the interface of discovery and development while championing biomarker-initiatives that have a direct impact on novel clinical study design.Responsibilities:Lead efforts to develop and implement translational biomarker strategies that assess proof of mechanism, establish early signs of efficacy and enable proof of concept studiesPartner with preclinical scientists to design and execute translational research to validate biomarker strategiesCollaborate with research and clinical teams to ensure the integration of biomarker discoveries into the design of early clinical studiesOversee clinical validation of biomarker assays and collaborate with clinical pharmacology in the analysis of clinical biomarker studiesContribute to discovery pipeline as a biology team representativeRequirements:PhD with primary focus in Immunology with at least 8 years of pharmaceutical or biotechnology industry experienceExperience in small molecule drug discovery and program leadershipExperience in the identification and validation of pharmacodynamic and disease biomarkers, as well as their clinical implementationAbility to drive and influence projects from discovery through early clinical development with a focus on the identification of indications and development of biomarker strategies that enable early proof-of-conceptOutstanding analytical, research and organizational skillsStrong interpersonal, influencing, and collaboration skillsAbility to prioritize, and be highly productive and flexible in a fast-paced, team-oriented environmentAbility to communicate scientific results to diverse audiences, in a clear and concise manner__________________________________________________________________A propos de nous :Nous sommes une société biopharmaceutique au stade clinique qui utilise sa plateforme exclusive de chimie computationnelle basée sur l'apprentissage automatique pour développer des traitements différenciés à base de petites molécules dans les domaines de l'immunologie, de l'inflammation et de la neurologie.Notre plateforme propriétaire de découverte de médicaments, ReSOLVE™, nous donne la capacité de découvrir et de développer des médicaments grâce à des connaissances uniques sur les cibles protéiques et de créer des plans dynamiques qui peuvent guider le développement de thérapies différenciées à un rythme rapide. Nous utilisons la plateforme ReSOLVE™ pour améliorer la façon dont les médicaments sont découverts et développés, dans le but ultime de restaurer la santé des personnes confrontées à des maladies graves.Aperçu du poste :Ventus est à la recherche d'un scientifique expérimenté pour diriger la conception et l'exécution de stratégies de biomarqueurs pour soutenir nos programmes de recherche en phase initiale et en phase avancée. Le candidat sera responsable du développement d'approches de biomarqueurs translationnels qui mesurent l'engagement de la cible, la pharmacodynamique et la pathologie de la maladie. En tant que leader stratégique au sein d'une équipe multidisciplinaire, le candidat veillera à ce que les stratégies de biomarqueurs s'alignent sur la compréhension la plus récente de la biologie des maladies inflammatoires et permettent une preuve de concept clinique précoce. On attend du candidat qu'il adopte une approche pratique de la validation préclinique de ces approches en utilisant des échantillons biologiques de la maladie. Ce poste est une occasion unique de travailler à l'interface de la découverte et du développement tout en défendant les initiatives en matière de biomarqueurs qui ont un impact direct sur la conception de nouvelles études cliniques.Responsabilités :Mener des efforts pour développer et mettre en œuvre des stratégies de biomarqueurs translationnels qui évaluent la preuve du mécanisme, établissent des signes précoces d'efficacité et permettent des études de preuve de conceptTravailler en partenariat avec des scientifiques précliniques pour concevoir et exécuter des recherches translationnelles afin de valider des stratégies de biomarqueursCollaborer avec les équipes de recherche et les équipes cliniques afin d'assurer l'intégration des découvertes en matière de biomarqueurs dans la conception des premières études cliniquesSuperviser la validation clinique des essais de biomarqueurs et collaborer avec la pharmacologie clinique pour l'analyse des études de biomarqueurs cliniquesContribuer au pipeline de découverte en tant que représentant de l'équipe de biologie Exigences :Doctorat en immunologie avec au moins 8 ans d'expérience dans l'industrie pharmaceutique ou biotechnologiqueExpérience de la découverte de médicaments à petites molécules et de la direction de programmesExpérience dans l'identification et la validation de biomarqueurs pharmacodynamiques et pathologiques, ainsi que dans leur mise en œuvre cliniqueCapacité à conduire et à influencer des projets depuis la découverte jusqu'au développement clinique précoce, en mettant l'accent sur l'identification des indications et le développement de stratégies de biomarqueurs permettant une validation précoce du conceptExcellentes compétences en matière d'analyse, de recherche et d'organisationSolides compétences en matière de relations interpersonnelles, d'influence et de collaborationCapacité à établir des priorités, à être hautement productif et flexible dans un environnement où le rythme est rapide et où l'esprit d'équipe est de miseCapacité à communiquer des résultats scientifiques à des publics divers, de manière claire et concise
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