Principal Investigator, Translational Science

3 weeks ago

Montréal QC, Canada Ventus Therapeutics Full time

About us: Ventus Therapeutics is a clinical-stage biopharmaceutical company deploying leading-edge structural biology and computational chemistry tools to create novel small molecule medicines for challenging targets in immunology, inflammation, and neurology.

Our proprietary drug discovery platform, ReSOLVE, gives us the ability to discover and develop medicines through unique insights into protein targets and to create dynamic blueprints that can guide the development of differentiated therapies at a fast pace. We aim to use the ReSOLVE platform to improve the way medicines are discovered and developed, with the ultimate goal of restoring the health of people facing serious illnesses.

Ventus is seeking an experienced translational scientist to lead the design and execution of biomarker strategies in support of our early and late-stage research programs. The candidate will be responsible for the development of translational biomarker approaches that measure target engagement, pharmacodynamics and disease pathology. As a strategic leader within a multidisciplinary team, the candidate will ensure that biomarker strategies align with the most current understanding of inflammatory disease biology and enable early clinical proof-of-concept. Partner with preclinical scientists to design and execute translational research to validate biomarker strategies
Collaborate with research and clinical teams to ensure the integration of biomarker discoveries into the design of early clinical studies
Oversee clinical validation of biomarker assays and collaborate with clinical pharmacology in the analysis of clinical biomarker studies
Contribute to discovery pipeline as a biology team representative

PhD with primary focus in Immunology with at least 8 years of pharmaceutical or biotechnology industry experience
Experience in the identification and validation of pharmacodynamic and disease biomarkers, as well as their clinical implementation
Ability to drive and influence projects from discovery through early clinical development with a focus on the identification of indications and development of biomarker strategies that enable early proof-of-concept
Outstanding analytical, research and organizational skills
Ability to prioritize, and be highly productive and flexible in a fast-paced, team-oriented environment
Ability to communicate scientific results to diverse audiences, in a clear and concise manner

__________________________________________________________________

Nous sommes une société biopharmaceutique au stade clinique qui utilise sa plateforme exclusive de chimie computationnelle basée sur l'apprentissage automatique pour développer des traitements différenciés à base de petites molécules dans les domaines de l'immunologie, de l'inflammation et de la neurologie.

Ventus est à la recherche d'un scientifique expérimenté pour diriger la conception et l'exécution de stratégies de biomarqueurs pour soutenir nos programmes de recherche en phase initiale et en phase avancée. En tant que leader stratégique au sein d'une équipe multidisciplinaire, le candidat veillera à ce que les stratégies de biomarqueurs s'alignent sur la compréhension la plus récente de la biologie des maladies inflammatoires et permettent une preuve de concept clinique précoce. Ce poste est une occasion unique de travailler à l'interface de la découverte et du développement tout en défendant les initiatives en matière de biomarqueurs qui ont un impact direct sur la conception de nouvelles études cliniques.

Travailler en partenariat avec des scientifiques précliniques pour concevoir et exécuter des recherches translationnelles afin de valider des stratégies de biomarqueurs
Collaborer avec les équipes de recherche et les équipes cliniques afin d'assurer l'intégration des découvertes en matière de biomarqueurs dans la conception des premières études cliniques
Superviser la validation clinique des essais de biomarqueurs et collaborer avec la pharmacologie clinique pour l'analyse des études de biomarqueurs cliniques
Contribuer au pipeline de découverte en tant que représentant de l'équipe de biologie


Doctorat en immunologie avec au moins 8 ans d'expérience dans l'industrie pharmaceutique ou biotechnologique
Expérience dans l'identification et la validation de biomarqueurs pharmacodynamiques et pathologiques, ainsi que dans leur mise en œuvre clinique
Capacité à conduire et à influencer des projets depuis la découverte jusqu'au développement clinique précoce, en mettant l'accent sur l'identification des indications et le développement de stratégies de biomarqueurs permettant une validation précoce du concept
Excellentes compétences en matière d'analyse, de recherche et d'organisation
Capacité à établir des priorités, à être hautement productif et flexible dans un environnement où le rythme est rapide et où l'esprit d'équipe est de mise

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