Principal Scientist I

7 days ago

Toronto, Canada Pyramid Consulting, Inc Full time

Immediate need for a talented Principal Scientist I. This is a 11+months contract opportunity with long-term potential and is located in Toronto, Ontario,Canada(Onsite). Please review the job description below and contact me ASAP if you are interested.


Job ID:24-48958

Pay Range: $35 - $40/hour. Employee benefits include, but are not limited to, health insurance (medical, dental, vision), 401(k) plan, and paid sick leave (depending on work location).

Key Responsibilities:


  • Department Description: The Vaccine Drug Substance Development (VDSD) within the Global Bioprocess Development (GBD) department actively supports process development of novel vaccine candidates utilizing techniques such as molecular engineering, viral cell culture, bacterial fermentation, molecular biology and supportive analytical techniques. Novel vaccine candidate are typically recombinant proteins produced in bacterial expression systems or attenuated viruses / glycosylated proteins produced in mammalian expressions system. In VDSD, we develop and scale up upstream and downstream processes for new vaccines up to 200L scale. Working within one of the most highly regulated industries, the candidate will have the opportunity to develop the ability to lead and function creatively within a team, while maintaining attention to strict compliance. The candidate will acquire knowledge of industry constraints and regulations.
  • Interphase with Global Antigen Design team to screen new vaccine candidate, design and improve various constructs through molecular engineering techniques and perform genetic stability testing.
  • Collaborate with Upstream Scientists and lead a team of Technologists to plan and execute upstream process optimization and scale-up studies using technologies such as AMBR high-throughput bioreactor system, small and pilot scale bioreactors.
  • Perform in-house or coordinate supportive analytical testing including viral titration assays, FACS, SDS-PAGE, Western blot, HPLC, protein assays, and others.
  • Perform statistical data analysis, prepare technical reports and stakeholder presentations.
  • Lead and/or contribute to characterization studies using Design of Experiments methodology.
  • Contribute to tech transfer of processes to Global Clinical manufacturing or Manufacturing Sciences and Technology.
  • Contribute to client’s digital initiatives (eg. AI).
  • Ensure compliance with client’s GxP quality, documentation requirements and HSE policies.


Key Requirements and Technology Experience:


  • Key Skills: molecular cloning, protein expression, mammalian cell culture .
  • Manager Notes: Must Have experience: molecular cloning (nucleic acid analysis, and protein expression), Experience with mammalian cell culture (eg. SF9, CHO, Vero) and Analytical techniques such as virus titration assays, FACS, protein assays, SDS-PAGE, Western blot, HPLC, and others .
  • Hands-on experience in molecular engineering tools (molecular cloning, nucleic acid analysis, and protein expression).
  • Knowledge and experience with bioprocessing methods and process scale-up.
  • Mandatory Computer skills: Word, Excel, Powerpoint.
  • Expertise in Statistical analysis and software (JMP, GraphPad Prism etc) would be an asset..
  • Soft skills ,Leadership skills ,Superior organizational skills .
  • Demonstrated accountability and motivation
  • Strong attention to detail and analytical skills
  • Excellent communication and interpersonal skills
  • Desire to work within a team environment
  • Recommended PhD with 1+ years’ experience or MSc with 3+ years’ experience in a Biochemical Engineering / Life Sciences / Biology / Immunology / Biochemistry disciplines
  • Languages: English proficiency.


Our client is a leading Pharmaceutical Industry, and we are currently interviewing to fill this and other similar contract positions. If you are interested in this position, please apply online for immediate consideration.


Pyramid Consulting, Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, colour, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.


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