Senior/Principal/Sr. Principal Scientist, Preclinical

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Overview
At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Position Summary
We are seeking a highly motivated senior scientist to join our translational and in-vivo pharmacology team and contribute to the development of innovative radioligand therapies. The successful candidate will be responsible for independently executing in vivo pharmacology studies to support the development of radioligand therapy. This role involves identifying clinically relevant models, piloting growth curves, and conducting efficacy studies. Additionally, the candidate will work closely with the pathology core to develop IHC protocols for tissue microarray staining.

Responsibilities

• Independently design, execute and interpret in-vivo pharmacology studies to support radioligand therapy development.
• Identify clinically relevant models and pilot growth curves and efficacy studies.
• Collaborate with the pathology core to develop IHC protocols for FFPE sample staining.
• Perform flow cytometry to analyze cell populations.
• Conduct in-vivo mechanism of action (MOA) studies.
• Manage studies through external vendor

Basic Requirements

• Senior Scientist: MSc degree in Molecular Biology or a related field with 1+ years of experience or BSc degree with 4+ years of experience.
• Principal Scientist: MSc degree in Molecular Biology or a related field with 4+ years of experience or BSc degree with 6+ years of experience.
• Sr. Principal Scientist: PhD degree in Molecular Biology or a related field with 1+ years of experience.
• Strong background in molecular biology and pharmacology in an oncology setting.
• Experience in animal handling, tumor cell implantation for developing in-vivo tumor models, tumor measurements, compound formulation and intravenous injections and necropsy.
• The position will observe typical business hours, Monday through Friday. Some weekend and holiday work may be required and will be communicated with ample notice.

Additional Preferences

• Strong experience with mammalian tissue culture. Experience with 3D organoid cultures will be an asset.
• Experience in developing IHC protocols and familiarity using tools for IHC image analysis and quantification of IHC images.
• Experience with radioactivity is considered an asset.
• Experience with live animal procedures under anesthesia (such as imaging) is considered a strong asset.
• Highly motivated and passionate about scientific research.
• Detail-oriented with strong organizational skills.
• Adaptable and able to thrive in a fast-paced environment.
• Innovative thinker with a proactive approach to problem-solving.
• Strong interpersonal skills and the ability to work effectively with cross-functional teams.
• Flexibility to work some evening weekday shifts on an occasional basis based on project needs.

Additional Information
Physical Demands/Travel:
The physical demands of this job are consistent with a lab environment
.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment
This position's work environment is in a Laboratory environment.

The
work
environment
characteristics
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representative of those an employee encounters while performing the essential functions of this job.

• To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is

$68,250 - $129,800

Full-time equivalent employees may also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a pension plan; vacation benefits; eligibility for healthcare benefits; flexible benefits (if applicable) life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.