Senior Principal Scientist

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

We are seeking a highly motivated Senior Principal Scientist to join our preclinical radiobiology and pharmacology team to contribute to the development of innovative radioligand therapies. The successful candidate will be responsible for independently executing in vivo pharmacology studies to support the development of radioligand therapy. This role involves a high degree of mammalian tissue culture and end-to-end execution of in vivo studies. This includes experimental design, tumor cell engraftment, formulation and administration of test compounds, and tissue collection. Additionally, the candidate will perform flow cytometry to identify and validate tumor models. The candidate will also critically assess data and methodology and bring forward project recommendations based on data that is generated.

Responsibilities:

• Independently design, execute and interpret data from multiple overlapping in-vivo pharmacology studies to support radioligand therapy development.
• Perform routine tissue culture of numerous mammalian cell lines simultaneously, including passaging, pathogen testing, and preparation for engraftment.
• Collaborate with chemistry, preclinical, translational and animal facility team members to obtain necessary materials and documentation for efficient execution of in vivo studies.
• Critically assess data and methods, adapting and adjusting procedures as necessary.
• In conjunction with managers, establish priorities and meet timelines for key experiments.
• Provide clear communication of scientific data to co-workers through internal presentations and written methods.
• Perform flow cytometry to analyze cell populations from in vitro and ex-vivo samples
• Interface with external vendors and partners to support early discovery activities.

Basic Requirements:

• PhD degree in oncology, immunology, biology, or similar scientific field.

Additional Preferences:

• 1-2 years of post-degree experience is preferred
• Demonstrated success independently designing experiments and planning multiple concurrent scientific projects.
• Strong experience with mammalian cell culture and aseptic techniques, including management of numerous cell lines simultaneously.
• Strong experience with flow cytometry, including independently validating and designing stain panels, sample preparation for staining, and interpretation of flow cytometry data.
• Experience in animal handling, tumor cell implantation for developing in-vivo tumor models, tumor measurements, compound formulation and intravenous injections and necropsy.
• Excellent organization, problem-solving and decision-making skills.
• Strong interpersonal skills and confidence in working in a fast-paced, team environment.
• Experience with Graphpad Prism, Flowjo and MS office.
• Experience with live animal procedures under anesthesia (such as imaging) is considered a strong asset.
• Experience with electronic lab notebooks is considered an asset.
• Experience in developing IHC protocols and familiarity using tools for IHC image analysis and quantification of IHC images is considered an asset.
• Experience with radioactivity is considered an asset.
• Highly motivated and passionate about scientific research.
• Adaptable and able to thrive in a fast-paced environment.
• Innovative thinker with a proactive approach to problem-solving.
• The position will observe typical business hours, Monday through Friday. Some weekend and holiday work may be required and will be communicated with ample notice.

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