Postdoctoral Fellowship in Islet and Beta Cell Biology

10 hours ago


Greater Montreal Metropolitan Area, Canada Institut de recherches cliniques de Montréal (IRCM) Montreal Clinical Research Institute Full time

Postdoctoral Fellowship in Islet and Beta Cell Biology

Therapeutic Development and In Vivo Beta Cell Targeting

The Estall Lab, within the Cardiometabolic Health Centre of the IRCM, invites applications for a Postdoctoral Fellowship in islet and beta cell biology, with a specialized focus on 
therapeutic development and in vivo beta cell targeting
. Our lab is dedicated to uncovering innovative strategies to treat diabetes through precise modulation of beta cell function and survival.

Research Focus

This academic- and industry-funded position offers the opportunity to contribute to cutting-edge projects aimed at:

  • Developing and evaluating the biological and physiological effects of novel therapeutics designed to enhance beta cell function and mass.
  • Designing and implementing strategies for in vivo targeting of beta cells.
  • Characterizing islet and beta cell responses to therapeutic interventions in preclinical models.
  • Employing advanced in vivo imaging, delivery technologies, and functional assays.

Qualifications

  • Ph.D. in Cell Biology, Physiology, Molecular Biology, Pharmacology, or a related field.
  • Research experience in islet biology is required, including techniques such as glucose tolerance testing, insulin secretion assays, and islet isolation and culture.
  • Hands-on experience with in vivo models of diabetes (e.g., STZ, NOD, or diet-induced obesity models) is required.
  • Experience with cell culture and standard molecular biology techniques (e.g. Western blotting, ELISAs, immunostaining, flow cytometry, cell signaling) is required.
  • Expertise in endocrine physiology and metabolic disease will be favoured.
  • Excellent problem-solving abilities, a strong work ethic, and the ability to work both independently and collaboratively.

We Offer

  • A vibrant research environment with access to state-of-the-art facilities.
  • A lab with strong expertise in diabetes and islet biology, and a highly collaborative and dynamic team.
  • Affiliation with the University of Montreal or McGill University.
  • Medical and dental benefits (through university affiliation).
  • Mentorship from established leaders in diabetes and beta cell biology (CIRTN network membership).
  • Opportunities for authorship, conference travel, industry internships, and career advancement.
  • Competitive salary range: $45,000 – 80,000 / yr (based on experience and successful external funding). Starting two-year contract with opportunities for renewal.

To Apply

Start date is flexible, but ideally before March 1
st
2026. Interested candidates should send a cover letter summarizing research interests and relevant experience, a current CV, and contact details for three references to:

Dr. Jennifer Estall

Websites: ,

Applications will be reviewed on a rolling basis until the position is filled.

Join our mission to translate scientific discovery into transformative diabetes therapies.


Stage postdoctoral en biologie des îlots de Langerhans et des cellules bêta

Développement thérapeutique et ciblage in vivo des cellules bêta

Le laboratoire Estall, au sein du centre de recherche en santé cardiométabolique de l'IRCM, lance un appel à candidatures pour un stage postdoctoral en biologie des îlots de Langerhans et des cellules bêta, avec une spécialisation dans
le développement thérapeutique et le ciblage in vivo des cellules bêta
. Notre laboratoire se consacre à la découverte de stratégies novatrices pour traiter le diabète par la modulation précise de la fonction et de la survie des cellules bêta.

Objectif de la recherche

  • Ce poste financé par IRSC et l'industrie offre l'opportunité de contribuer à des projets de pointe visant à:
  • Développer et évaluer les effets biologiques et physiologiques de nouveaux agents thérapeutiques conçus pour améliorer la fonction et la masse des cellules bêta.
  • Concevoir et mettre en œuvre des stratégies de ciblage in vivo des cellules bêta.
  • Caractériser les réponses des îlots et des cellules bêta aux interventions thérapeutiques dans des modèles précliniques.
  • Utiliser des technologies avancées d'imagerie et d'administration in vivo, ainsi que des essais fonctionnels.

Qualifications

  • Diplôme de doctorat d'un collège/université accrédité en biologie cellulaire, physiologie, biologie moléculaire, pharmacologie ou dans un domaine connexe.
  • Expérience en recherche dans le domaine de la biologie des îlots de Langerhans requise, y compris dans des techniques telles que les tests de tolérance au glucose, les tests de sécrétion d'insuline et l'isolement et la culture d'îlots de Langerhans.
  • Expérience pratique avec des modèles in vivo de diabète (par exemple, STZ, NOD ou modèles d'obésité induite par le régime alimentaire) est requise.
  • Expérience requise en culture cellulaire et en techniques standard de biologie moléculaire (par exemple, Western blotting, ELISA, immunomarquage, cytométrie en flux, signalisation cellulaire).
  • Une expertise en physiologie endocrinienne et en maladies métaboliques sera un atout.
  • Excellentes capacités de résolution des problèmes, forte éthique de travail et capacité à travailler à la fois de manière indépendante et en collaboration.

Nous offrons

  • Un environnement de recherche dynamique avec accès à des installations de pointe.
  • Un laboratoire avec une forte expertise dans le domaine du diabète et de la biologie des îlots de Langerhans, ainsi qu'une équipe très collaborative et dynamique.
  • Affiliation à l'Université de Montréal ou à l'Université McGill.
  • Prestations médicaux et dentaires (à travers l'affiliation à l'université).
  • Mentorat par de leaders reconnus dans le domaine du diabète et de la biologie des cellules bêta (adhésion au R2FIC).
  • Possibilités de publication, de participation à des conférences, de stages dans l'industrie et d'avancement professionnel.
  • Salaire compétitif : à dollars par an (en fonction de l'expérience et de l'obtention d'un financement externe). Contrat de deux ans avec possibilité de renouvellement.

Pour postuler

La date d'entrée en fonction est flexible, mais idéalement avant le 1er mars 2026. Les candidats intéressés doivent envoyer une lettre de motivation résumant leurs intérêts de recherche et leur expérience, un CV à jour et les coordonnées de trois personnes de référence à :

Dre Jennifer Estall

Sites web: ,

Les candidatures seront examinées au fur et à mesure jusqu'à ce que le poste soit pourvu.

Rejoignez notre mission de traduire les découvertes scientifiques en thérapies transformatrices pour le diabète.



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