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Montreal, Quebec, Canada OP Consulting Full timeWe are looking for a Postdoctoral Researcher,Bioanalytical Scientist,to join for the 24 month contract opportunity at Thryv Therapeutics.Thryv Therapeutics Inc. (previously LQT Therapeutics Inc.) is a privately owned company based in Montreal, Quebec, Canada. Thryv Therapeutics is pioneering a precision medicine approach to treat genetic and drug-induced...
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Postdoctoral Researcher
2 weeks ago
We are looking for a
Postdoctoral Researcher, Analytical Chemistry, to join for the 24 month contract opportunity at Thryv Therapeutics.
(Version française ci-dessous)
Thryv Therapeutics Inc. (previously LQT Therapeutics Inc.) is a privately owned company based in Montreal, Quebec, Canada. Thryv Therapeutics is pioneering a precision medicine approach to treat genetic and drug-induced Long QT Syndromes, atrial fibrillation and resistant cancers with potent and selective inhibitors of Serum Glucocorticoid inducible Kinase.
SUMMARY
Thryv Therapeutics is seeking a highly skilled and motivated Postdoctoral Researcher with expertise in LCMS method development and validation to join the team for the 24 months contract. The selected candidate will provide analytical support for both synthetic chemists and biologists, analyzing samples from chemical syntheses, in vitro biological assays, and occasionally plasma or blood matrices. This position offers the opportunity to work cross-functionally in a fast-paced, innovative drug discovery setting.
KEY RESPONSIBILITIES
- Develop, optimize, and validate LCMS methods for quantitative and qualitative analysis of small molecules, biological assay samples, and biological fluids (plasma, blood, etc.).
- Collaborate closely with synthetic chemistry teams to analyze reaction mixtures, intermediates, and final products.
- Work alongside biologists to analyze samples generated from in vitro assays and other biological experiments.
- Perform routine maintenance, troubleshooting, and calibration of LCMS instrumentation to ensure reliable operation and data quality.
- Document analytical methods, results, and instrument maintenance according to regulatory and scientific best practices.
- Assist with preparation of scientific reports, publications, and presentations.
QUALIFICATIONS
- PhD in Analytical Chemistry, Chemistry, Biochemistry, or related field with hands-on experience in LCMS method development and validation.
- Proven track record in developing LCMS methods for complex sample matrices, ideally including biological fluids.
- Experience with LCMS instrument maintenance and troubleshooting.
- Strong data analysis skills and ability to interpret complex analytical results.
- Excellent problem-solving, organizational, and communication skills.
- Strong ethics, integrity, and commitment to scientific excellence.
- Highly organized and able to prioritize projects.
- Ability to collaborate effectively in cross-disciplinary research teams
- Excellent written and verbal communication skills.
- Motivation to work independently with guidance, and initiative to meet deadlines.
EQUAL OPPORTUNITY WORKPLACE
Thryv Therapeutics is proud to be an equal opportunity employer. We are committed to equal employment opportunity regardless of race, colour, religion, sex, sexual orientation, gender identity, age, national origin, disability, and any other characteristic protected by law.
À propos de nous
Thryv Therapeutics Inc. (anciennement LQT Therapeutics Inc.) est une entreprise privée basée à Montréal, Québec, Canada. Thryv Therapeutics est pionnière d'une approche de médecine de précision visant le traitement des syndromes du QT long d'origine génétique ou induits par des médicaments, de la fibrillation auriculaire et de cancers résistants, grâce à des inhibiteurs puissants et sélectifs de la kinase induite par les glucocorticoïdes sériques (SGK).
Poste :
Thryv Therapeutics recherche un(e) chercheur(euse) postdoctoral(e) hautement qualifié(e) et motivé(e), possédant une expertise en développement et validation de méthodes LC-MS, pour un contrat de 24 mois. La personne retenue fournira un soutien analytique aux équipes de chimie de synthèse et de biologie, en analysant des échantillons issus de synthèses chimiques, d'essais biologiques in vitro et, occasionnellement, de matrices biologiques telles que le plasma ou le sang. Ce poste offre l'opportunité de travailler de façon transversale dans un environnement de découverte de médicaments innovant et dynamique.
Les responsabilités incluent :
- Développer, optimiser et valider des méthodes LC-MS pour l'analyse quantitative et qualitative de petites molécules, d'échantillons d'essais biologiques et de fluides biologiques (plasma, sang, etc.).
- Collaborer étroitement avec les équipes de chimie de synthèse pour analyser des mélanges réactionnels, des intermédiaires et des produits finaux.
- Travailler en collaboration avec les biologistes pour analyser des échantillons provenant d'essais in vitro et d'autres expériences biologiques.
- Effectuer l'entretien courant, le dépannage et l'étalonnage des instruments LC-MS afin d'assurer un fonctionnement fiable et une qualité de données élevée.
- Documenter les méthodes analytiques, les résultats et la maintenance des instruments conformément aux meilleures pratiques scientifiques et réglementaires.
- Contribuer à la préparation de rapports scientifiques, de publications et de présentations.
Formation, expérience et compétences :
- Doctorat (PhD) en chimie analytique, chimie, biochimie ou dans un domaine connexe, avec une expérience pratique en développement et validation de méthodes LC-MS.
- Expérience démontrée dans le développement de méthodes LC-MS pour des matrices complexes, idéalement incluant des fluides biologiques.
- Expérience en maintenance et dépannage d'instruments LC-MS.
- Solides compétences en analyse de données et capacité à interpréter des résultats analytiques complexes.
- Excellentes aptitudes en résolution de problèmes, en organisation et en communication.
- Sens élevé de l'éthique, intégrité et engagement envers l'excellence scientifique.
- Grande capacité d'organisation et aptitude à prioriser les projets.
- Capacité à collaborer efficacement au sein d'équipes de recherche multidisciplinaires.
- Excellentes compétences en communication écrite et orale.
- Motivation à travailler de manière autonome, avec encadrement, et sens de l'initiative pour respecter les échéanciers.
Milieu de travail équitable
Thryv Therapeutics est fière d'être un employeur offrant l'égalité des chances. Nous nous engageons à offrir des chances d'emploi égales, sans discrimination fondée sur la race, la couleur, la religion, le sexe, l'orientation sexuelle, l'identité de genre, l'âge, l'origine nationale, le handicap ou toute autre caractéristique protégée par la loi.
