Research Associate Ii, in Vivo Pharmacology and

Job Req ID: 701- Location: Vancouver, BC, CAN- Additional Locations: N/A- Department: In Vivo Pharmacology & PK**Research Associate II, In Vivo Pharmacology and Pharmacokinetics**:
**Company Description**

**Why Work With Us**

Nothing is more critical to our success than the quality of our team. The work we do is meaningful and impactful - we care about each other as well as the patients we serve. We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

This position will report to the Group Lead, In Vivo Pharmacology and PK and will be a hybrid position, based in Vancouver, BC.

Zymeworks is proudly headquartered in our brand new, net-zero facility located in the vibrant Main St biotech hub of Vancouver, BC, with operations in Seattle, WA and Dublin, Ireland. We offer a hybrid work environment with most team members working in-office three days per week.

**Key Responsibilities**:

- Evaluates samples from preclinical in vivo mouse pharmacology models to enable translation of cancer therapies.
- Leads routine analysis of biological samples using ELISA, MSD and flow cytometry assays with a high degree of reliability, efficiency and accuracy.
- Perform isolation and culture of lymphocyte populations from human and mouse blood or tissues for pharmacodynamic analysis.
- Develops, troubleshoots, and qualifies more complex bioanalytical methods for the characterization and quantification of biotherapeutics.
- Coordinates sample management including sample collection, transportation, organization and archiving. Maintains compete and accurate records throughout the process
- Maintains high levels of productivity, organization, and teamwork in the laboratory including the use of inventory management systems
- Documents raw data and performs data analysis. May independently interpret results and present data.
- Responsible for maintaining laboratory reagent stocks and updating inventory documents.
- Completes study reports and maintains adequate experimental records in compliance with company’s standards.
- Generates high quality methods and study protocols for internal programs.
- Recommends technical strategies and approaches to meet identified research needs.
- Implements techniques to improve productivity, increase efficiencies and maintain laboratory state-of-the-art practices.
- Conducts all activities in accordance with scientific standards, OH&S regulations and established policies and practices.
- Fosters effective and collaborative working relationships with fellow employees, management and external partners.

**Additional Responsibilities**
- Assist with mammalian tissue culture, including the maintenance of multiple tumor cell lines using sterile technique, as well as the expansion, cryopreservation and thawing of cell lines as needed.
- Thaws and prepares human immune cells for intravenous injection into mice
- Aid in a variety of established cell-based in vitro assays for functional characterization of bispecific antibodies as needed.
- Prepares basic written reports and analysis of experiments. Consults with others for data interpretation. Communicates results and analysis to working group.
- Seeks to understand ongoing projects through attention to scientific literature and internally generated data.

**Qualifications and Experience**:

- Requires a BSc in a scientific discipline and a minimum of 3 years’ related experience, or MSc and an equivalent combination of education and experience.
- An equivalent combination of education and experience may be considered.
- Embody and champion Zymeworks’ values: Act with Integrity. Collaborate. Care.
- Adhere to the highest degree of professional standards and strict confidentiality on matters that require discretion.

**Skills and Abilities**
- Experience with mammalian cell culture and cell-based assays is required.
- Demonstrated experience with immunoassay (ELISA, MSD) method development and qualification/validation is preferred.
- Experience with characterization and analysis of biotherapeutics (antibodies, FC-fusion proteins and ADCs) using immunoassays or other analytical methods is preferred.
- Ability to evaluate immune cells via flow cytometry is an asset
- Experience with in-vivo animal models would be an asset.
- GLP experience in the core competencies of characterization and analysis of biotherapeutics would be an asset.
- Exceptional analytical and problem-solving capabilities.
- Strong organizational skills and the ability to work effectively in a high paced, fast changing environment. Results oriented.
- Effective oral communication and scientific/technical writing skills. Ability to present data at team meetings or interdepartmental meetings.
- Proven interpersonal skills with the ability to work collaboratively as a member of a cross-functional team. Ability to establish and maintain effective working relationships.

**Total Rewards**

We offer a comprehensive total r