Research Associate I, Translational Biology

Company:
Chronic kidney disease (CKD) is a serious and growing global health challenge, affecting approximately 1 in 7 people worldwide. In the absence of effective treatments, patients may progress to kidney failure, requiring dialysis or transplantation—placing a significant burden on patients, families, and healthcare systems. While recent advances have benefited certain subsets of kidney disease patients, many common forms of CKD still lack effective therapeutic options.

Borealis was founded on the belief that the convergence of scientific and translational breakthroughs can unlock the potential of RNA therapeutics to address some of the most rare and underserved kidney diseases—and beyond. Borealis builds on the success of Chinook Therapeutics, a kidney disease company with a research site in Vancouver that was acquired by Novartis in 2023 for $3.5 billion. The Borealis team has strong leadership and academic advisors with deep experience and expertise in both kidney disease and RNA therapeutics. Headquartered in Vancouver, BC, Borealis operates state-of-the-art wet labs equipped for molecular and cellular biology, in vivo pharmacology, chemistry, DMPK, bioinformatics, and analytical sciences.

Position:
Responsibilities include:

- Perform, analyze, and interpret in vitro and ex vivo endpoint assays to support the advancement of platform development goals and preclinical drug discovery programs.
- Assist in the development of in vitro models to investigate target biology and underlying mechanisms.
- Assist team members with in vivo study takedowns and sample collection for end point analyses.
- Review research literature to inform experimental designs and contribute to overall project advancement.
- Prepare clear and concise study protocols and technical reports and maintain accurate records in an electronic lab notebook (ELN).
- Present experimental data and findings in team meetings and contribute to scientific discussions.
- Support the maintenance of a clean, organized, and fully functional laboratory environment.
- Foster and contribute to a collaborative, team-oriented, and positive company culture.

**Location**:

- This is an on-site lab-based position located in Borealis Bio's Vancouver, BC headquarters. Most of your time will be spent conducting wet lab work.

Education, Experience, and Skills:

- B.Sc. degree in a relevant scientific discipline and hands-on research experience— preferably in an industrial setting.
- Direct experience in handling in vivo samples including plasma, serum, urine and tissues —exposure to in vivo necropsy and tissue collection techniques is a plus.
- Extensive experience in cell culture, qPCR, and ELISA techniques.
- Strong working knowledge of cellular biology, molecular biology, and biochemistry.
- Proficient with Microsoft Office Suite and GraphPad Prism; experience with ELNs, such as Benchling or Dotmatics, is a plus.
- Strong time management skills and ability to thrive in a fast-paced, cross-functional team environment.
- Adaptability to shifting priorities and changing workloads.
- A collaborative team player with a genuine passion for science and drug discovery.
- Demonstrates a positive attitude, integrity, and high personal and ethical standards.
- Borealis is an Equal Opportunity Employer, and we prohibit discrimination or harassment of any kind. We are committed to fostering an environment where ALL people are welcome and supported. _We cultivate a culture of inclusion for all employees that respects their individual strengths, views, and experiences. We believe that our differences enable us to be a better team - one that makes better decisions, drives innovation, and delivers better business results. Creativity and innovation flourish in an environment of openness, inclusion, and mutual respect._