Principal Bioinformatics Scientist II

3 weeks ago

Mississauga, Ontario, Canada Roche Full time
About Roche

At Roche, we're driven by a passion for innovation and a commitment to improving healthcare. With over 100,000 employees across 100 countries, we're one of the world's leading research-focused healthcare groups. Our success is built on curiosity, diversity, and a relentless pursuit of excellence.

The Opportunity

We're seeking a Principal Bioinformatics Scientist to join our NGS Algorithms and Applications team. As a key member of our team, you'll collaborate closely with assay scientists, software engineers, and other bioinformatics scientists to develop innovative algorithms for next-generation sequencing technologies. Your expertise will be instrumental in designing and developing algorithms for read processing, alignment, and variant calling, which will be used in our products that impact patient care.

Responsibilities
  • Lead algorithm development efforts for NGS applications, including conceptualization, method development, and implementation of production-level algorithms in an Agile environment.
  • Follow software development processes and deliver and maintain documentation that explains why and how, as well as the final design, for scientific, marketing, and regulatory uses.
  • Present internally or externally (peer-reviewed publications or conference proceedings) and communicate updates across multiple functions in the organization. Transfer algorithms to production teams and provide scientific support for updates and maintenance.
  • Support bioinformatics pipeline development for existing products.
Requirements
  • PhD in Bioinformatics, Computational Biology, Computer Science, Statistics, Mathematics, or other quantitative field combined with 7+ years of industry/post-doc experience designing novel algorithms for NGS data analysis.
  • 2+ years of experience in developing novel algorithms, complexity analysis, and demonstrated skills in statistical and mathematical modeling.
  • Experience implementing high-quality and efficient product-level code.
  • 2+ years of experience with sequencing (long and/or short read), cancer molecular biology, bioinformatics tools, statistical methods.
  • Proficient with programming languages (C++) in a distributed Linux environment.
  • Hands-on experience using a workflow management system such as Nextflow or Snakemake, using Docker and cloud computation resources and storage.
Preferred Qualifications
  • One or more first/co-first author publication(s) in a high-impact peer-reviewed journal.
  • Experience with Machine learning/Deep learning (used in NGS context).
What We Offer

At Roche, we offer a dynamic and inclusive work environment that fosters collaboration, innovation, and growth. We're committed to supporting our employees' professional development and well-being. If you're passionate about bioinformatics and committed to improving healthcare, we encourage you to apply for this exciting opportunity.

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