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Research Scientist ADME RLT
1 week ago
At Eli Lilly and Company, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism.
Overview:
We make a difference for people around the globe by discovering, developing, and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you can count on us to develop creative solutions to support communities through philanthropy and volunteerism.
Position Summary:
The ADME Scientist will be responsible for analyzing new candidate radioligands being developed as part of POINT's discovery pipeline. This role involves performing analytical methods to profile the distribution, metabolism, and clearance of experimental pharmaceuticals being tested in vivo and in vitro. The ideal candidate will have technical experience with inductively coupled plasma analyzers, liquid chromatography/mass spectrometry analysis methods, familiarity with handling and analysis of biological samples, and experience working with radioactive materials.
Responsibilities:
- Prepare biological samples for analysis, including digestion of cultured cells and animal tissues.
- Analyze samples using instrumental methods to assess properties of candidate therapeutics.
- Perform metabolite profiling of biological samples using mass spectrometry for both non-radioactive and radioactive ligands.
- Quantify metals in animal tissue sections using ICP-MS.
- Measure ligand concentrations in biological samples using radiometric LC/MS or related approaches.
- Conduct research work independently and collaboratively with senior scientists to support discovery and preclinical activities.
- Maintain analytical equipment to ensure consistent and high-quality data collection.
- Document experimental details and results accurately.
- Manage time effectively and prioritize tasks to meet project deadlines.
- Ensure a safe working environment by adhering to health and safety protocols and regulatory requirements governing hazardous chemicals and radioactive materials.
