Biotechnology Research Associate

1 week ago

Vancouver, British Columbia, Canada Zymeworks Full time
Job Summary

We are seeking a highly skilled and motivated Senior Research Associate I to join our Protein Engineering team at Zymeworks. As a key member of our team, you will be responsible for planning, executing, and optimizing purification workflows of multispecific antibody therapeutics.

Key Responsibilities
  • Independently plan, perform, and optimize purification workflows of multispecific antibody therapeutics using AKTA (FPLC) systems, gravity flow columns, and high-throughput plate-based methods.
  • Perform analytical and biophysical characterization of antibodies and other protein therapeutics for quality control, stability, and developability studies.
  • Plan, execute, and evaluate binding studies using SPR, BLI, Kinexa, and/or flow cytometry methods, either independently or in collaboration with teammates.
  • Analyze and review data, draw conclusions, and make recommendations for future investigations.
  • Initiate and execute novel methods and/or suggest innovative and impactful changes to methods independently or in collaboration with team members.
  • Participate in cross-departmental collaborative activities and present data at departmental and project team meetings.
  • Seek to understand ongoing projects through attention to scientific literature, industry publications, and internally generated data and employs this understanding to improve contribution to project goals.
  • Maintain a clean, organized, and operational lab.
  • Conduct all activities in accordance with scientific standards, OH&S regulations, and established policies and practices.
  • Actively work to foster an environment of effective and collaborative working relationships across the organization.
  • Adhere to Zymeworks' standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic laboratory notebook.
Requirements
  • Requires a MSc in a relevant scientific discipline with 3-5 years of relevant work experience, or equivalent combination of education and work experience.
  • Good working knowledge and hands-on experience in several of the following areas: Protein purification (e.g. protein A/G/L, IEX, IMAC, and SEC) and familiarity with AKTA (FPLC) systems.
  • Experience with developability and stability assessments of antibody-based therapeutics would be desirable.
  • Good organizational and time management skills, work effectively in a fast-paced, fast-changing environment.
  • Good critical observation with analytical and problem-solving capabilities.
  • Good communication skills, including scientific/technical writing and oral skills. Ability to present data effectively at team meetings and inter-departmental meetings.
Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. Our salary ranges are determined by role, level, and location. The Canadian base salary range for this full-time position is $73,000 - $, + bonus + equity + benefits. Our team enjoys:

  • Industry-leading vacation and paid time off.
  • Excellent health and wellness benefits.
  • Zymelife health and wellness benefits.
  • Paid time off to volunteer in your community.
  • Matching country-specific pension savings program.
  • Employee Share Purchase Program.
  • Employee Equity Program.

All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, or disability.

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